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Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Religion (and spirituality) is very much alive and shapes the cultural values and aspirations of psychiatrist and patient alike, as does the choice of not identifying with a particular faith. Patients bring their beliefs and convictions into the doctor-patient relationship. The challenge for mental health professionals, whatever their own world view, is to develop and refine their vocabularies such that they truly understand what is communicated to them by their patients. Religion and Psychiatry provides psychiatrists with a framework for this understanding and highlights the importance of religion and spirituality in mental well-being. This book aims to inform and explain, as well as to be thought provoking and even controversial. Patiently and thoroughly, the authors consider why and how, when and where religion (and spirituality) are at stake in the life of psychiatric patients. The interface between psychiatry and religion is explored at different levels, varying from daily clinical practice to conceptual fieldwork. The book covers phenomenology, epidemiology, research data, explanatory models and theories. It also reviews the development of DSM V and its awareness of the importance of religion and spirituality in mental health. What can religious traditions learn from each other to assist the patient? Religion and Psychiatry discusses this, as well as the neurological basis of religious experiences. It describes training programmes that successfully incorporate aspects of religion and demonstrates how different religious and spiritual traditions can be brought together to improve psychiatric training and daily practice. Describes the relationship of the main world religions with psychiatry Considers training, policy and service delivery Provides powerful support for more effective partnerships between psychiatry and religion in day to day clinical care This is the first time that so many psychiatrists, psychologists and theologians from all parts of the world and from so many different religious and spiritual backgrounds have worked together to produce a book like this one. In that sense, it truly is a World Psychiatric Association publication. Religion and Psychiatry is recommended reading for residents in psychiatry, postgraduates in theology, psychology and psychology of religion, researchers in psychiatric epidemiology and trans-cultural psychiatry, as well as professionals in theology, psychiatry and psychology of religion

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.

This new Fourth Edition of Financial Management of Health Care Organizations, offers an introduction to the most-used tools and techniques of health care financial management, including health care accounting and financial statements; managing cash, billings and collections; making major capital investments; determining cost and using cost information in decision-making; budgeting and performance measurement; and pricing. New to this edition: The Perspectives sections and the glossary have been updated. The book features a cutting-edge view of the health care landscape in 2013 and beyond after passage and pending implementation of the Affordable Care Act. Areas of expanded content include revised examples of financial statements for both private non-profit hospitals and investor-owned hospital management companies, changes in bad debt and charity care, the role of financial statements, the discount rate or cost of capital, lease financing section, use of cost information, budgeting, cost centers, and current forms of reimbursement Content new to this edition includes valuation of accounts receivable and the «waterfall» effect of cash collections, differences between Posting-Date and Service-Date reporting methodologies, calculation of effective annual interest rate, application of time value of money in perspectives, and Activity-Based Costing from the perspective of labor, supplies, and equipment.

The New Prescriber is a comprehensive, accessible textbook that provides essential coverage of the three core components for prescribing: the client/patient, the evidence, and the pharmacology. Divided into three sections, this text first looks at the consultation with the patient, and outlines legal, professional and ethical frameworks which guide medical and non-medical prescribing. The second section is devoted to evidence-based practice, highlighting key skills essential to all clinicians. This section encourages the student to identify why evidence-based practice should underpin prescribing decisions. The third and final section is concerned with pharmacology. The student is introduced to basic concepts of pharmacodynamics and pharmacokinetics, adverse drug reactions and variability of response. The importance of these pharmacological principles is highlighted throughout the subsequent discussion of drug groups affecting major body systems. Key features: Pulls together all key elements of prescribing using an integrated approach ‘Stop and Think' boxes and practice application activities provided throughout, enabling the reader to link theory to practice Key terms and glossary provided This text is invaluable for all nursing, health and medical students taking courses in prescribing and pharmacology.

Changing demographics and evolving technology continuously affect maternal-fetal medicine Increasing maternal age and weight during pregnancy, higher rates of pregnancies conceived by artificial reproductive technologies and growing numbers of cesarean deliveries have led to a rise in the incidence of complicated pregnancies. The options have also increased for monitoring maternal and fetal health throughout a pregnancy, and identifying and managing risk earlier. For the maternal-fetal physician, constant vigilance throughout a pregnancy remains essential. But continuous change makes this an increasing challenge. Queenan’s Management of High-Risk Pregnancy covers the full spectrum of perinatal care. It guides you through the tough and complex decisions needed to protect the health of both your fetal and the maternal patients. New material in the 6th edition covers contemporary issues such as: Iron-deficient anemia Malaria Pregnancy in the disabled woman Placenta accreta Induction of labor Operative vaginal delivery Patient safety in labor and delivery The stellar cast of expert authors provide evidence, algorithms, case studies and potential outcome measures to ensure that Queenan's Management of High-Risk Pregnancy continues to set the bar for maternal-fetal practice. Titles of Related Interest Stillbirth Edited by Catherine Y. Spong ISBN 978-1-4443-3706-8 The Placenta: From Development to Disease Edited by Helen Kay, D. Michael Nelson and Yuping Wang ISBN 978-1-4443-3366-4 Pregnancy in the Obese Woman: Clinical Management Edited by Deborah E. Conway ISBN 978-1-4051-9648-2

Unrelieved chronic pain is a worldwide epidemic Chronic pain has been subject to multiple international initiatives through the World Health Organization. Interventional Pain Medicine, the use of minimally invasive techniques to relieve pain, is the best approach when simpler measures such as physical therapy or medications fail. However, these procedures can be associated with significant risk and expense. Establishing uniformity in diagnostic criteria and procedural performance can reduce both morbidity and unnecessary procedures, and hence healthcare expenditures. While other texts explain how to perform these procedures, little focus has been given to diagnostic considerations: if and when these procedures should be performed. Evidence-Based Interventional Pain Medicine focuses on a balance between effectiveness and safety of interventional management for specific diagnoses, across all areas of chronic pain including: Head, neck and shoulder pain Lower back pain Neuropathic pain syndromes Complex Regional Pain Syndrome Pain in patients with cancer Vascular and visceral pain Evidence-Based Interventional Pain Medicine provides essential knowledge for anyone who uses, or intends to use, interventional pain techniques.

This easy-to-use manual provides a practical framework for a multi-disciplinary team to deliver a successful cardiac rehabilitation programme. Despite evidence that cardiac rehabilitation programmes reduce risk, there is no standard for hospital-based multidisciplinary programmes – which are thus complex and costly to design and implement Based on the cardiac rehabilitation work that has been carried out at in Gloucestershire over the past fifteen years, developing and constantly evaluating the evidence base for the programme Includes client handouts such as food and exercise diaries

Provides students and practitioners with a clear, concise introduction to the statistics they will come across in their regular reading of clinical papers. Written by three experts with wide teaching and consulting experience, Medical Statistics: A Textbook for the Health Sciences, Fourth Edition: Assumes no prior knowledge of statistics Covers all essential statistical methods Completely revised, updated and expanded Includes numerous examples and exercises on the interpretation of the statistics in papers published in medical journals From the reviews of the previous edition: «The book has several excellent features: it is written by statisticians, is.... well presented, is well referenced.... and is short.» THE LANCET «Many statisticians are concerned at the generally poor standard of statistics in papers published in medical journals. Perhaps this could be remedied if more research workers would spare a few hours to read through Campbell and Machin's book.» BRITISH MEDICAL JOURNAL «… a simple, interesting and insightful introduction to medical statistics… highly recommended.» STATISTICAL METHODS IN MEDICAL RESEARCH «Campbell and Machin found the golden mean… this book can be recommended for all students and all medical researchers.» ISCB NEWSLETTER

Praise for Transforming Health Care Leadership «The authors of this book provide the necessary tools for health care leaders to build a learning organization that can make the Triple Aim a reality—better patient care, at lower per-capita cost, while learning to improve population health.» —Donald M. Berwick, MD, MPP, FRCP, president emeritus and senior fellow, Institute for Healthcare Improvement; former administrator, Centers for Medicare & Medicaid Services «This book is a must for every nurse leader's library and should be a resource and tool in every graduate nursing program, particularly those who are preparing doctoral students focused on systems leadership. It is full of experiential learning, and brings leadership to life.» —Alexia Green, RN, PhD, FAAN, professor and dean emeriti, Anita Thigpen Perry School of Nursing, Texas Tech University Health Sciences Center «At a time when bold changes are necessary in the delivery of health services to improve outcomes and lower costs, the authors provide both compelling reasons for change and specific case studies of how it can be done. This is an important resource for leaders at every level in every part of the health sector today. It should be required reading for all those who want to improve the performance of their part of our medical enterprise.» —John Rother, president and CEO, National Coalition on Health Care «Transforming Health Care Leadership is a well-constructed guide to transforming health care by creating transformational leadership. Anyone serious about improving health care—who has hope that we can actually succeed at making things better for our patients and communities while practicing good financial stewardship—needs to read this book.» —Tony Joseph, MD, founder, The Healthcare Accreditation Colloquium

Benefit-risk assessment is at the centre of the approval process for every new medicine. The ability to assess the risks of a new medicine accurately and to balance these against the benefits the medicine could bring is critical for every regulatory authority and pharmaceutical company. Despite this there are very few tried and tested evaluative models currently available. The authors of this book have developed a new, pioneering tool for the assessment of benefits and risks for new medicines in development. This model utilises a multi-criteria decision analysis which involves selecting, scoring and weighting key benefit and risk attributes and leads to an overall appraisal of benefits and risks of medicines. Benefit-Risk Appraisal of Medicines establishes the background and criteria required to assess benefit and risk in general and reviews the current practices by regulatory authorities and the pharmaceutical industry, including those models currently available. It outlines the development and evaluation of the authors’ new model and analyses the implications of its implementation. Describes an innovative, systematic model which leads to transparent and responsible benefit-risk decision making Contributes important ideas to the debate on benefit-risk appraisal Provides a future framework for benefit-risk appraisal of medicines Benefit-Risk Appraisal of Medicines covers the entire process from the discovery of new medicines to their marketing and is ideal for all those who work in the pharmaceutical industry and regulatory authorities,, as well as post-graduate students of pharmaceutical medicine and clinical pharmacology.