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How can prenatal testing help your patients? In utero diagnosis has undergone an amazing revolution in recent years. More tests are available; the indications for prenatal diagnosis have expanded – you can now advise your patients about disorders you could not have previously detected. Medical training for obstetricians, medical geneticists, and genetic counselors has not kept pace with these developments. Clinical exposure to common and unusual problems in prenatal diagnosis is limited. Prenatal Diagnosis: Clinical Cases and Challenges, based on the authors’ several decades of experiences, fills this gap. Real cases portray diagnostic problems as a route to the underlying biology, the available testing options, and the results that might be obtained. The authors discuss the challenges of management, interpretation, and counseling. Cases used throughout emphasize three types of clinical problems: Chromosomal abnormalities Mendelian disorders Fetal structural abnormalities The decision to enter the world of prenatal diagnosis should be very carefully considered by any prospective mother. Prenatal Diagnosis: Clinical Cases and Challenges will help you discuss the issues in an informed manner with your patients.

Plastic and reconstructive surgery continues to evolve as new techniques open up new possibilities for the surgeon. In this groundbreaking textbook, contemporary approaches are explained and demonstrated to allow trainee and experienced surgeons alike to understand and assimilate best practice. Containing over 300 outstanding color figures demonstrating surgical practice, an international cast of leading surgeons show the paths to effective plastic surgery technique and outcomes. They cover all the major bases including: Integument Pediatric Plastic Surgery Head and Neck Reconstruction The Breast Trunk, Lower Limb and Sarcomas Upper Limb and Hand Surgery Aesthetic Surgery Comprehensive in scope, practical in nature, Plastic and Reconstructive Surgery is your one-stop guide to successful surgical management of your patients. «This textbook is aimed at the trainee and young plastic surgeon, but it is extremely comprehensive and sufficiently detailed for any practitioner. The information is succinct, yet complete and up to date. . . . For a single-volume book, the detailed knowledge presented is impressive. . . . I think this is a great book. It is packed with good and up-to-date information, and I think it will be an invaluable resource for trainees but also for all plastic surgeons. The editors are to be congratulated on achieving a very difficult task with such success.» —from a review by Peter C. Neligan, MB, in Plastic and Reconstructive Surgery «This is exactly what the editors of Plastic and reconstructive surgery: Approaches and Techniques set out to achieve in producing this excellent textbook. . . . It is truly an international effort at all levels, as the editors, from Australia (Ross D. Farhadieh), the UK (Neil W. Bulstrode) and Canada (Sabrina Cugno), have joined forces to recruit over 130 international contributors and produce a resource of over 1100 pages that provides a well-organized and thorough, yet succinct, text of the essentials of current plastic surgery. . . .Many of the contributors are world-renowned experts; however, there is also a new generation of young rising stars whose contributions are equally good, providing a new, fresh and contemporary feel.» —from the Foreword by Julian J. Pribaz, Professor of Surgery, Harvard Medical School «The authors here have concentrated all this useful information into their chapters in a quite outstanding manner. Any plastic surgeon of whatever maturity will find this an excellent purchase which he/she will have no reason to regret.» —from a review by Douglas H. Harrison in Journal of Plastic, Reconstructive & Aesthetic Surgery

Barrier, reservoir, target site – those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous system such as autism, epilepsy and schizophrenia (to name but a few), discover more about the processes that cause the uncontrolled growth associated with cancer and develop possible treatments. Building Brains provides a highly visual and readily accessible introduction to the main events that occur during neural development and the mechanisms by which they occur. Aimed at undergraduate students and postgraduates new to the field, who may not have a background in neuroscience and/or molecular genetics, it explains how cells in the early embryo first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity including that arising from experience, and why some neurons normally die. Key Features: A concise illustrated guide focusing on the core elements of current understanding of neural development, emphasising common principles underlying developmental mechanisms and supplemented by suggestions for further reading. Text boxes throughout provide further detail on selected major advances, issues of particular uncertainty or controversy and examples of human diseases that result from abnormal development. A balanced mammalian/non-mammalian perspective, drawing on examples from model organisms including the fruit fly, nematode worm, frog, zebrafish, chick, mouse, ferret, cat, monkey and human, and emphasising mechanisms that are conserved across species. Introduces the methods for studying neural development including genetics, transgenic technologies, advanced microscopy and computational modeling, allowing the reader to understand the main evidence underlying research advances. Student-friendly, full colour artwork reinforces important concepts; an extensive glossary and definitions in page margins help readers from different backgrounds; chapter summaries stress important points and aid revision. Associated Website includes a complete set of figures from the textbook.

The development of new drugs is very complex, costly and risky. Its success is highly dependent on an intense collaboration and interaction between many departments within the drug development organization, external investigators and service providers, in constant dialogue with regulatory authorities, payers, academic experts, clinicians and patient organizations. Within the different phases of the drug life cycle, drug development is by far the most crucial part for the initial and continued success of a drug on the market. This book offers an introduction to the field of drug development with a clear overview of the different processes that lead to a successful new medicine and of the regulatory pathways that are used to launch a new drug that are both safe and efficacious. “This is the most comprehensive and detailed book on drug development I have ever read and I feel that it is likely to become a staple of drug development courses, such as those taught at Masters Level in my own University…. I think in the light of increasing integration of company and academic approaches to drug development both sides can read this book.. (and, therefore)… this book could not be more timely. “ Professor Mike Coleman, University of Aston., UK ( from his review of the final manuscript)

An accessible, essential introduction to forensic odontology. Written by a team of well-established, active practitioners in the field, Forensic Odontology is invaluable for those needing an introduction to the subject for the general dental practitioner who has an interest in forensic dentistry and is contemplating practicing in the field. It will also be useful as a reference during practice. After a brief introduction the book covers dental anatomy and development, expert witness skills, mortuary practice, dental human identification, disaster victim identification, dental age assessment, bite marks, forensic photography and the role of the forensic odontologist in protection of the vulnerable person. Chapters outline accepted and recommended practices and refer to particular methodologies, presenting different schools of thought objectively.

This handbook provides a short, contemporary text on the management of dentofacial deformities. The importance of a well organised, inter-disciplinary approach is emphasised throughout and the following key areas are presented: A detailed account of the role of the psychologist, from initial assessment through to post-operative support. A systematic approach to dentofacial assessment, including a section on diagnostic records and an overview of cephalometry. A logical step-by-step approach to treatment planning, emphasising the interactive thought process required when setting orthodontic and surgical objectives. The fundamentals of surgical orthodontics, with the scope and limitations of orthodontic appliances clearly explained for each phase of treatment. A description of orthognathic technical procedures and how potential errors can be minimised in order to improve the accuracy of model surgery. An account of how to carry out photo-cephalometric profile prediction planning, including a critique of the method. A detailed description of the full range of mandibular and maxillary orthognathic surgical procedures, including indications and complications. A chapter on higher-level osteotomies for the treatment of more severe craniofacial abnormalities is included for completeness. A series of six contrasting case studies. There is an emphasis on the technological advances that are rapidly enabling the global paradigm shift from 2D to 3D planning.

This pocket reference guide is a must for all medical students and junior doctors preparing for exams in pharmacology or needing a rapid reminder during a clinical attachment. In light of the growing pressures on those who prescribe drugs to patients, increasing emphasis has been placed on the importance of pharmacology in the undergraduate medical curriculum. Rapid Clinical Pharmacology, with its concise, easy-to-use approach, offers an appealing format for students to use in both clinical practice and exam preparation and its ‘one-page per drug/class' layout easily facilitates the generation of a personal student formulary. Each chapter of the book mirrors each section of the BNF to allow easy cross-referencing and then each chapter is divided into consistent sections as per other books in the Rapid series. Rapid Clinical Pharmacology will also be available as a mobile application for iPhone, iPod Touch, iPad and Blackberry. See wiley.com/go/mededapps for further details.

This timely and relevant new edition of an established and well-regarded text is essential reading for those training to become health visitors and those who are practitioners working with and in the community. Health Visiting: A Rediscovery has been thoroughly revised and updated to reflect the many new developments in health policy, public health priorities and health visiting practice. The focus of the book, however, remains the same: placing the health visitor at the forefront of supporting and working with children and families, ensuring the child has the best possible start in life. The increasing importance of working with communities and reaffirming the public health role of the health visitor are discussed and debated. The new edition takes into account the challenges and increasing need for health visitors to engage with research evidence and to evaluate their practice. Key features: Incorporates the practice of public health and working with communities Includes a brand new chapter on the importance of safeguarding children and the enhanced child protection role of the health visitor Timely and topical Essential reading for all nurses working in the community, those training as Specialist Community Public Health Nurses and undergraduate students undertaking public health, primary and community care course units Features case studies and learning activities

Veterinary Euthanasia Techniques: A Practical Guide provides detailed guidance on euthanasia procedures in a wide variety of species, including dogs, cats, exotics, horses, and production animals. Based on the current AVMA guidelines, the book offers step-by-step descriptions of the recommended methods of euthanasia, giving all the information needed to perform these techniques with confidence. Veterinary Euthanasia Techniques helps practitioners, students, and technicians expand their knowledge base and provide competent, compassionate euthanasia services. Including information on client considerations, equipment, positioning, sedation, and aftercare, the focus of the book is on providing detailed procedures for correctly performing euthanasia. Veterinary Euthanasia Techniques presents complete information on euthanasia, offering specific advice to improve skills and aid in decision making.

Interprofessional Rehabilitation: a Person-Centred Approach is a concise and readable introduction to the principles and practice of a person-centred interprofessional approach to rehabilitation, based upon a firm scientific evidence base. Written by a multi-contributor team of specialists in physiotherapy, occupational therapy, nursing, psychology and rehabilitation medicine, this text draws together common themes that cut across the different professional groups and the spectrum of health conditions requiring rehabilitation, and sets out a model of practice that is tailored to the specific needs of the client. Showing interprofessionalism at work in a range of clinical contexts, the book argues that effective rehabilitation is best conducted by well-integrated teams of specialists working in an interdisciplinary way, with the client or patient actively involved in all stages of the process. This book will be essential reading for students preparing for practice in an increasingly interprofessional environment, and will be of interest to any health care practitioner keen to understand how an integrated approach to rehabilitation can benefit their clients.

Tinnitus: A Multidisciplinary Approach provides a broad account of tinnitus and hyperacusis, detailing the latest research and developments in clinical management, incorporating insights from audiology, otology, psychology, psychiatry and auditory neuroscience. It promotes a collaborative approach to treatment that will benefit patients and clinicians alike. The 2nd edition has been thoroughly updated and revised in line with the very latest developments in the field. The book contains 40% new material including two brand new chapters on neurophysiological models of tinnitus and emerging treatments; and the addition of a glossary as well as appendices detailing treatment protocols for use in an audiology and psychology context respectively.