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This book describes clearly how legislation can be used to advance the rights and entitlements of people with mental health problems. Straightforward and practical, it provides useful information on how to address disabilities so these people may enjoy full citizenship. It presents the key issues succinctly and illustrates these with legislative examples from around the world. This book documents the role that law can play, at all levels, in combating such discrimination and abuse.

Substance abuse disorders are among the most prevalent psychiatric disorders and are frequently comorbid with other psychiatric and health conditions and accompanied by social problems; however, they remain under-recognized and under-treated. Many physicians and mental health practitioners receive little-to-no training in the identification and treatment of these disorders. Approaches to their prevention include some of the major success stories in modern public health as well as some of the deepest controversies in public life. This new title in the WPA series Evidence and Experience in Psychiatry informs psychiatrists and a wide range of professional groups from health and social services about these disorders and their treatment and control. 'Highly Commended' in the Psychiatry section of the 2012 BMA Book Awards

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process. No other publication offers the same level of treatment on this crucial topic in modern drug development.

Introducing the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition. It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species. Based on the authors’ extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful. • An essential manual for daily diagnostic work • Richly illustrated with high quality colour gross, histological and MRI images • Includes a section on the function and use of MRI (by Johann Lang, DECVDI) • Accompanied by a website presenting MRI sequences for interpretation and correlation with neuropathological findings edited by Johann Lang (University of Bern, Switzerland) and Eric Wiesner (University of California, Davis, USA)

Allay your anxieties about the MRCP exams and increase your confidence with An Aid to the MRCP: Essential Lists, Facts and Mnemonics. In order to pass the MRCP exams you will need to learn a large number of lists and key facts. This book provides the essential lists and facts you need to know together with memory aids to speed learning and recall. Armed with this knowledge you will be able to rapidly narrow your differential diagnosis and identify the most likely answer. This essential new MRCP title has been written by a recent candidate for the MRCP exams who used this technique to pass first time, in conjunction with Dr Bob Ryder, Dr Anne Freeman and Dr Mir Afzal; all established authorities in the MRCP field and authors of the two volumes of An Aid to the MRCP PACES. An Aid to the MRCP: Essential Lists, Facts and Mnemonics presents memory aids, facts and lists that are based on questions faced whilst revising for, or encountered during the MRCP exams and also features a free audio revision tool at www.anaidtothemrcp.com with a summary of the mnemonics contained in the book.

The importance of appropriate and effective management of patient with long term chronic conditions cannot be underestimated. Case Management of Long-Term Conditions aims to provide all appropriate practitioners (including nurses, pharmacists, physiotherapists, and social care practitioners) who might be involved in delivery of proactive case management with a practical understanding of how their knowledge and skills can be utilised to improve outcomes for people with chronic long-term conditions. The text contains some broad reflections on care and service delivery based on reviews of evidence and views from clinicians in the use of these skills and competencies to deliver improved outcomes for clients.

Coeliac Disease: Nursing Care and Management provides nurses with the knowledge and evidence base to understand the impact of the diagnosis of Coeliac disease, and examine the long term treatment and management of the condition. The authors take the reader through an investigative journey from the history of the disease through its pathology, characteristics, diagnosis, treatment and management. Clinical case studies bring to life both the physical and psychosocial aspects of care of patients making this an ideal text for clinical nurse specialists, Gastroenterology nurses and Endoscopy nurses.

The second edition of Clinical Dilemmas in Inflammatory Bowel Disease: New Challenges, is a practical, up-to-date handbook providing expert guidance on specific clinical dilemmas and areas of difficulty that the gastroenterologist regularly faces in day-to-day practice. In this new edition, 75% of the “dilemmas” are brand new dilemmas facing the IBD specialist concerning emerging treatment therapies, such as the use of cannabinoids and Viagra for Crohn’s disease. The remaining 25% of the dilemmas are fully updated from the previous edition, incorporating the latest clinical thinking. Each of the 57 evidence-based chapters contains clear learning points, addresses different topics, and provides sound guidance on subjects ranging from optimizing current management through to special management problems and novel treatments. This book is suitable for all medical professionals involved in the care of patients with IBD: established and trainee gastroenterologists, colorectal surgeons, pathologists, radiologists, specialist nurses, pharmacists, dieticians and counselors.

This book explains the ecology of viruses by examining their interactive dynamics with their hosting species (in this volume, in microbes and plants), including the types of transmission cycles that viruses have evolved encompassing principal and alternate hosts, vehicles, and vectoring species. Examining virology from an organismal biology approach and focusing on the concept that viral infections represent areas of overlap in the ecologies of the involved species, Viral Ecology is essential for students and professionals who either may be non-virologists or virologists whose previous familiarity has been very specialized.

Now in its second edition, Health Communication: From Theory to Practice provides a comprehensive introduction to theory, intervention design, current issues, and special topics in health communication. The book also represents a hands-on guide to program development, implementation, and evaluation. This second edition further emphasizes the importance of a people-centered and participatory approach to health communication interventions, which takes into account key social determinants of health as well as the interconnection of various health and social fields. While maintaining a strong focus on the importance of behavioral, social, and organizational results as key outcomes of health communication interventions, this second edition also includes new or updated information, theoretical models, resources, and case studies on: Health equity Urban health New media Emergency and risk communication Strategic partnerships in health communication Policy communication and public advocacy Cultural competence Health literacy The evaluation of health communication interventions To access a companion website with instructor resources (PowerPoint presentations for all chapters, sample assignments, and other resources), please visit www.wiley.com/go/schiavo2e This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the «right» drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development. Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume: Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics Address developability issues that challenge pharma companies, moving beyond isolated experimental results Reveal connections between the key scientific areas that are critical for successful drug discovery and development Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.