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This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.

This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

Role Emerging Occupational Therapy: Maximising Occupation Focused Practice is written for an audience of occupational therapy practitioners, educators and students. This text offers an exploration of emerging innovative directions for the profession of occupational therapy with a focus upon the theory and application of role emerging placements. The book affords the reader an opportunity to explore how occupation focused practice can be applied to a wide variety of settings and circumstances in order to improve the health and well-being of a diverse range of people. Chapters cover relevant theory as well as offering practical guidance with examples drawn from the experiences of university educators, occupational therapists, setting/service providers and students. The book describes, explores and discusses both the potential and ramifications of role emerging practice on the occupational therapy profession and offers a vision for the future of the profession that reflects current occupational, social and health needs.

In the twentieth century, the urban settings of the wealthy nations were largely associated with opportunity, accumulation of wealth, and better health than their rural counterparts. In the twenty-first century, demographic changes, globalization, and climate change are having important health consequences on wealthy nations and especially on low- and middle-income countries. The increasing concentration of poverty and significant inequalities between urban neighborhoods and the physical and social environments in cities are important determinants of population health. In this important new book, experts identify the priority problems and outline solutions that can generate and sustain healthy urban environments. Foreword by Michael H. Bloomberg Contributors include: Sue Atkinson, John G. Bartlett, Angela Beaton, Karl Brown, Pamela Ligouri Bunker, Robert J. Bunker, Scott Burris, Waleska Teixeira Caiffa, Roel A. Coutinho, Manuel Carballo, Ruth Colagiuri, Beatriz de Faria Leao, Amélia Augusta de Lima Friche, Alex Ezeh, Geoff Green, Claudio Giulliano da Costa Octavio Gómez-Dantés, Ruth Finkelstein, Julio Frenk, Nicholas Freudenberg, Fu Hua, Sandro Galea, Ticia Gerber, Carola Hein, Catherine Hull, Tord Kjellstrom, Jacob Kumaresan, Catherine Ronald Labonté, Stephen Leeder, Godfrey Mbarauku, Gordon McGranahan, Patricia Monge, Mark R. Montgomery, Martin Mulenga, Ana Luiza Nabuco, Julie Netherland, Ndioro Ndiaye, Rougui Ndiaye-Coïc, Kalala Ngalamulume, Danielle Ompad, Stipe Oreskovic, Ariel Pablos-Méndez, Jonathan Parkinson, Fernando Augusto Proietti, Thomas C. Quinn, Carlos E. Restrepo, Kevin J. Robinson, Jonathan M. Samet, David Satterthwaite, Richard H. Schneider, Ted Schrecker, Elliott Sclar, Maria Steenland, Agis Tsouros, Arnoud P. Verhoeff, Nicole Volavka-Close, Michael Ward, Vanessa Watson, Rae Zimmerman.

The Placenta: From Development to Disease examines research into placental function and its clinical implications to provide a springboard for improving clinical practice and enhancing medical research. Influential information is extracted from the compelling narrative by the use of 'take home' features including: Clinical Pearls – point to important issues in clinical practice Research Spotlights – highlight key insights into placental understanding Teaching Points – explain basic concepts for novice readers The Placenta: From Development to Disease is ideal for both experienced clinicians and researchers and those new to the field. Anyone who needs to understand the central importance of the placenta in the well being of their maternal and fetal patients should read this book.

Written by leading clinicians and research experts in the fields of child development and psychopathology, this book is an authoritative and up to date guide for psychologists, psychiatrists, paediatricians and other professionals working with vulnerable children. The opening chapters outline neurobiological, genetic, familial and cultural influences upon child development, especially those fostering children's resilience and emotional wellbeing. Discussion of the acquisition of social and emotional developmental competencies leads on to reviews of child psychopathology, clinical diagnoses, assessment and intervention. Developed with busy professionals and trainees in mind, it is comprehensively yet concisely written, using visual aids to help the reader absorb information rapidly and easily. This book is an essential purchase for those working or training in all clinical and community child settings.

Leadership, expertise, and collaborative working are fundamental aspects of efficient and effective healthcare. This book offers a comprehensive overview of the general theories, principles and points of good practice in each of these three areas. This general literature is then contextualised by theoretical and practical implications for maternity care, and illustrated with in-depth case studies of successful innovation and change in practice. Essential reading for all midwives, midwifery students, and others working in or studying maternity care, this book helps readers understand the theoretical underpinnings of effective leadership, expertise and collaborative ways of working. Special features: Part of the acclaimed Essential Midwifery Practice series A theoretical and practical exploration of the nature and application of leadership, expertise and collaborative working in midwifery Provides inspirational case studies of change and innovation Brings together national and international experts in the field

The basic and applied toxicology of cyanides and cyanogens has widespread commercial, occupational, environmental, clinical, forensic, military, and public health implications. This book provides a detailed and updated reference describing the properties, uses, general and human toxicology, clinical recognition, diagnosis and medical management, and countermeasures is therefore required in academic, medical, occupational, environmental, medico-legal, regulatory, emergency response, and military arenas. Edited by a world-renowned team of experts from academia, defense and industry, this book will be an invaluable reference for professionals, researchers and students in cyanide and cyanogens.

New edition fully includes Grades and Levels of evidence, providing a better idea of what the sum total of existing evidence suggests regarding key topics Grades and levels of evidence consistently highlighted throughout Greater number of tables and algorithms («decision trees») for key decision-making areas «Scope of concept» introduction to chapters are significantly enhanced, allowing the reader to reference the concepts while reviewing the specific details in the clinically oriented chapters The only available book with an evidence-based approach covering this specific subject matter in one compendium

The patient interview is at the heart of psychiatric practice. Listening and interviewing skills are the primary tools the psychiatrist uses to obtain the information needed to make an accurate diagnosis and then to plan appropriate treatment. The American Board of Psychiatry and Neurology and the Accrediting Council on Graduate Medical Education identify interviewing skills as a core competency for psychiatric residents. The Psychiatric Interview: Evaluation and Diagnosis is a new and modern approach to this topic that fulfils the need for training in biopsychosocial assessment and diagnosis. It makes use of both classical and new knowledge of psychiatric diagnosis, assessment, treatment planning, and doctor–patient collaboration. Written by world leaders in education, the book is based on the acclaimed Psychiatry, Third Edition, by Tasman and Kay et al., with new chapters to address assessment in special populations and formulation. The psychiatric interview is conceptualized as integrating the patient’s experience with psychological, biological, and environmental components of the illness. This is an excellent new text for psychiatry residents at all stages of their training. It is also useful for medical students interested in psychiatry and for practicing psychiatrists who may wish to refresh their interviewing skills.

This book explains the correct logical approach to analysis of forensic scientific evidence. The focus is on general methods of analysis applicable to all forms of evidence. It starts by explaining the general principles and then applies them to issues in DNA and other important forms of scientific evidence as examples. Like the first edition, the book analyses real legal cases and judgments rather than hypothetical examples and shows how the problems perceived in those cases would have been solved by a correct logical approach. The book is written to be understood both by forensic scientists preparing their evidence and by lawyers and judges who have to deal with it. The analysis is tied back both to basic scientific principles and to the principles of the law of evidence. This book will also be essential reading for law students taking evidence or forensic science papers and science students studying the application of their scientific specialisation to forensic questions.

"An excellent primer on medical imaging for all members of the medical profession . . . including non-radiological specialists. It is technically solid and filled with diagrams and clinical images illustrating important points, but it is also easily readable . . . So many outstanding chapters . . . The book uses little mathematics beyond simple algebra [and] presents complex ideas in very understandable terms." —Melvin E. Clouse, MD, Vice Chairman Emeritus, Department of Radiology, Beth Israel Deaconess Medical Center and Deaconess Professor of Radiology, Harvard Medical School A well-known medical physicist and author, an interventional radiologist, and an emergency room physician with no special training in radiology have collaborated to write, in the language familiar to physicians, an introduction to the technology and clinical applications of medical imaging. It is intentionally brief and not overly detailed, intended to help clinicians with very little free time rapidly gain enough command of the critically important imaging tools of their trade to be able to discuss them confidently with medical and technical colleagues; to explain the general ideas accurately to students, nurses, and technologists; and to describe them effectively to concerned patients and loved ones. Chapter coverage includes: Introduction: Dr. Doe's Headaches Sketches of the Standard Imaging Modalities Image Quality and Dose Creating Subject Contrast in the Primary X-Ray Image Twentieth-Century (Analog) Radiography and Fluoroscopy Radiation Dose and Radiogenic Cancer Risk Twenty-First-Century (Digital) Imaging Digital Planar Imaging Computed Tomography Nuclear Medicine (Including SPECT and PET) Diagnostic Ultrasound (Including Doppler) MRI in One Dimension and with No Relaxation Mapping T1 and T2 Proton Spin Relaxation in 3D Evolving and Experimental Modalities