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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout the book, practical examples compiled from both the author's and other researchers' previous clinical trial experiences are discussed in a sequential manner as they occur in the study, starting from the development of the clinical protocol and the selection of clinical sites and ending with the completion of the final clinical study report. Next, readers are guided through the development of important clinical documents, including informed consent forms, case report forms, and study logs. A careful review of the Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) regulations applicable to medical devices is also featured. Additional coverage includes: Qualification and selection of investigators Study monitoring visits Definitions and reporting procedures for adverse events The use of biostatistical methodology in clinical research, including the use of biostatistics for sample size determination and study endpoints The roles and responsibilities of all members of a clinical research team The book concludes with an insightful discussion of special ethical conduct for human research and challenging issues to consider during the design of clinical studies. A glossary lists important clinical and statistical terms used in clinical research, and an extensive reference section provides additional resources for the most up-to-date literature on the topic. Design, Execution, and Management of Medical Device Clinical Trials is an excellent book for clinical research or epidemiology courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for clinical research associates, clinical managers, clinical scientists, biostatisticians, pharmacologists, and any professional working in the field of clinical research who would like to better understand clinical research practices.

Authored by members of the British Bobath Tutors Association, Bobath Concept: Theory and Clinical Practice in Neurological Rehabilitationis a practical illustrated guide that offers a detailed exploration of the theoretical underpinning and clinical interventions of the Bobath Concept. The evolution of the Bobath concept is brilliantly captured in this volume. The recognition that the best inhibition may come from engaging the patient in normal activities is an example of the way one of the notions central to the original Bobath Concept has developed. In short, the Bobath Concept lies at the heart of an approach to neurorehabilitation that is ready to take advantage of the rapidly advancing understanding, coming from neuroscience, of brain function in, in particular, of the effects of and responses to damage, and the factors that may drive recovery. It is no coincidence that neuroplasticity figures so prominently in the pages that follow.’ Emeritus Professor Raymond Tallis BM BCh BA FRCP FMedSci LittD DLitt FRSA This book guides the reader through general principles to more specific application of neurophysiological principles and movement re-education in the recovery of important areas, including moving between sitting and standing, locomotion and recovery of upper limb function. Bobath Concept: Theory and Clinical Practice in Neurological Rehabilitationwill be invaluable to undergraduate and qualified physiotherapists /occupational therapists and all professionals working in neurological rehabilitation. Covers the theoretical underpinning of the Bobath Concept. Presents a holistic, 24-hour approach to functional recovery. Focuses on efficient movement and motor learning, to maximise function. Forges links between theory and clinical practice. Illustrated throughout.

Written by Peter J. Fos—an expert in epidemiology with more than twenty years teaching experience—Epidemiology Foundations offers an ideal introduction to the theory and practice of public health epidemiology. This important text discusses both the historical perspective and future trends of epidemiology, reviews health and disease, and explains how they are measured. The book's overview of epidemiological studies shows how they are used in practice. Epidemiology Foundations takes a social and community perspective and includes information about global diseases and epidemics. Emphasis on concepts such as population health, social determinants, and global health make this book especially interesting and accessible to those new to the subject. Each chapter is supplemented with problem-solving exercises and research assignments to aid readers in understanding its epidemiology principles. Reflecting and expanding on recommendations of the Association of American Colleges and Universities, Epidemiology Foundations is the ideal text for any course introducing epidemiology in public health.

The Pre-hospital Obstetric Emergency Training (POET) programme provides an introduction to the obstetric patient and the anatomical and physiological changes that occur during pregnancy (including interpretation of patient-held records and rapid assessment of the obstetric patient). It includes clear definitions and describes risk factors, diagnosis and pre-hospital management of significant problems that occur in both early and late pregnancy and the immediate postnatal period. These are all situations that the pre-hospital practitioner may attend. This text and the accompanying integrated on-line and ‘hands on’ course will help practitioners identify and manage a range of time-critical obstetric emergencies specifically in the pre-hospital setting, and provides a structured examination and assessment technique as an aid to determining what treatment should be provided before transport, as well as when and how urgently transport should be initiated. POET is of relevance to paramedics, ambulance staff, doctors, and nurses working in the emergency pre-hospital setting and to midwives facilitating home births. It will also be of considerable value to medical and nursing practitioners working in Emergency Departments and unscheduled care settings where immediate access to skilled obstetric assistance is not available.

‘Best of the Best’ solutions to challenging reconstructive surgery of the nose The nose, with its unique and individual topography, presents particular challenges for reconstructive and skin cancer surgeons. A number of approaches can be adopted, but how does the dermatologic surgeon choose the best for any particular defect? Reconstructive Conundrums in Dermatology: The Nose provides an atlas compendium of novel approaches to these challenges. Based on the Reconstructive Conundrum series published in the journal Dermatologic Surgery, a range of cases provide photographs of the defect before and immediately after reconstruction, and two long-term, follow-up images. The authors provide a detailed explanation for their choice of reconstruction. The Editors’ commentaries allow residents and experienced surgeons alike to compare different reconstructive alternatives and to explore the thought processes behind them. The 30 conundrums each provide a full background to the problem and the strategies underpinning successful surgical solution. They have been grouped into nasal subunits covering: Nasal dorsum Nasal sidewall Nasal tip Nasal ala Alar groove Alar rim Jam packed with clinical wisdom and surgical pearls, Reconstructive Conundrums in Dermatologic Surgery: The Nose provides a guiding hand to anyone faced with daunting surgical reconstructions.

This fourth, updated edition contains the latest developments in analytical techniques. An international team of authors summarizes the information on biological influences, analytical interferences and on the variables affecting the collection, transport and storage, as well as preparation of samples. In so doing, they cover age, gender, race, pregnancy, diet, exercise and altitude, plus the effects of stimulants and drugs. National and international standards are described for sampling procedures, transport, sample identification and all safety aspects, while quality assurance procedures are shown for total laboratory management. In addition, this practical book contains a glossary as well as a separate list of analytes containing the available data on reference intervals, biological half-life times, stability and influence and interference factors. For everyone involved in patient care and using or performing laboratory tests.

Male genitourethral abnormalities are a source of great concern and distress to those affected. Surgery, when required, is very specialized and often extremely complex requiring expert surgical skills in order to achieve the best outcomes. Atlas of Male Genitourethral Surgery: The Illustrated Guideprovides urological surgeons, at all levels of experience from trainees to established specialists, with a full colour, highly illustrated and step-by-step approach to male genitourethral surgery, enabling complete mastery of surgical techniques in this difficult and challenging area. Full-color throughout and with over 430 high-quality images, this comprehensive atlas covers key areas of urologic surgery including: Surgery for penile curvature Urethral reconstruction and artificial urinary sphincters Penile and scrotal reconstruction Surgery for male infertility Surgery for erectile dysfunction Surgery for penile cancer Each chapter includes an introduction to the condition and its challenge, a step-by step guide to the surgical procedures applicable for that condition with surgical tips and tricks for improved techniques and outcomes. Brought to you by the world’s leading experts in the field of genitourethral surgery, this outstanding book guides you through the most challenging of operations, helping you deliver high quality clinical care to your patients.

Translated into seven languages, Cotton and Williams' Practical Gastrointestinal Endoscopy has for the last 25 years been the basic primer for endoscopy around the world, providing clear, clinical and practical guidance on the fundamentals of endoscopy practice, from patient positioning and safety, how to perform different endoscopic procedures, and the latest in therapeutic techniques and advances in technology. It's key strength and reason for its popularity is its step-by-step, practical approach, especially with the use of outstanding colour artwork to illustrate the right and wrong ways to perform endoscopy. Add to this the weight and expertise of its author team, led by Peter Cotton and Christopher Williams, and the final result is an essential tool for all gastroenterologists and endoscopists, particularly trainees looking to improve their endoscopic technique. Joining Peter Cotton, Christopher Williams and Brian Saunders in the seventh edition are two exciting stars in UK and US endoscopy, Adam Haycock and Jonathan Cohen. New to this edition are: Approximately 35 high-quality videos illustrating optimum endoscopy practice, all referenced via “video eyes” in the text Self-assessment MCQs to test main learning points An online clinical photo imagebank to complement the line illustrations, perfect for downloading into scientific presentations Key learning points in every chapter Much more information on mucosal resection techniques and small bowel endoscopy—for capsule and “deep” enteroscopy The latest recommendations and guidelines from the ASGE, ASG, UEGW and BSG. Cotton and Williams' Practical Gastrointestinal Endoscopy, seventh edition is fully modernised, masterful as ever, and once again, the number one endoscopy manual for a whole new generation of gastroenterologists and endoscopists.

Veterinary Anesthesia and Analgesia: the Fifth Edition of Lumb and Jones is a reorganized and updated edition of the gold-standard reference for anesthesia and pain management in veterinary patients. Provides a thoroughly updated edition of this comprehensive reference on veterinary anesthesia and analgesia, combining state-of-the-art scientific knowledge and clinically relevant information Covers immobilization, sedation, anesthesia, and analgesia of companion, wild, zoo, and laboratory animals Takes a body systems approach for easier reference to information about anesthetizing patients with existing conditions Adds 10 completely new chapters with in-depth discussions of perioperative heat balance, coagulation disorders, pacemaker implantation, cardiac output measurement, cardiopulmonary bypass, shelter anesthesia and pain management, anesthetic risk assessment, principles of anesthetic pharmacology, and more Now printed in color, with more than 400 images

This new resource provides a basic foundation in small animal anatomy for students of veterinary medicine, animal science, and veterinary technology. Extraordinary accuracy and beautiful original artwork make this a truly unique learning tool that includes the anatomy of all organ systems in the dog, cat, rabbit, rat, and guinea pig – all described in a consistent manner. Learning features include: carefully selected labeling helps students learn and remember structures and relationships; male and female of species are depicted on facing pages so topographic anatomy can be compared; structures common to various animals are labeled several times, whereas unique structures are labeled on one or two species so students can make rapid distinctions of the structures peculiar to certain animals; and an introduction that provides readers with a background in nomenclature and anatomic orientation so they can benefit from the atlas even if they lack training in anatomy. The Atlas depicts topographic relationships of major organs in a simple, yet technically accurate presentation that's free from extraneous material so that those using the atlas can concentrate on the essential aspects of anatomy. It will be an invaluable resource for veterinary students, teachers and practitioners alike.

Are you interested in using NOTES to treat your patients? Do you need a multimedia tool to guide you through all aspects of clinical management? Just as laparoscopic surgery revolutionized surgical practice in the 1980’s and 90’s, offering genuine competition to traditional open surgery, Natural Orifice Translumenal Endoscopic Surgery (NOTES) presents a genuinely different alternative for surgeons and patients alike as we move forward in the 21st century. Advantages over laparoscopic surgery include lower anesthesia requirements, faster recovery and shorter hospital stays, avoidance of transabdominal wound infections, less immunosuppression, better postoperative pulmonary and diaphragmatic function and of course, the potential for «scarless» abdominal surgery. Combining high-level text with a superb companion website, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas provides you with a hands-on, in-depth and practical multimedia tool on this exciting breakthrough, to consult either on the ward or in surgery. Highlights include: Full coverage of the fundamentals of NOTES, its current clinical applications and techniques, and future perspectives Over 50 outstanding videos illustrating NOTES being performed by the experts Full-color throughout and superbly illustrated with over 250 figures Edited by global leaders and pioneers in the field, who have recruited a world-class contributor team As well being a valuable text for gastroenterologists, GI surgeons and general surgeons, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas will also appeal to urologists, urologic surgeons, gynecologists, gynecologic surgeons, thoracic and ENT surgeons.