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This book covers the developmental and health problems unique to the adolescent period of life. It focuses on special needs and public health programs for adolescents. It offers deep insight into smoking, violence, teen pregnancy, HIV/AIDS, and other problems, along with intervention and prevention strategies. «Anyone serious about improving adolescent health should read this book. It spans theoretical and developmental constructs, summaries of evidence-based interventions for adolescent risk behaviors, metrics, and policy recommendations.» —S. Jean Emans, MD, chief, Division of Adolescent Medicine, and Robert Masland Jr., chair, Adolescent Medicine, Children's Hospital Boston, and professor of pediatrics, Harvard Medical School «This is the one single text that students can use to study adolescent health. It includes contributions from many of the world's most accomplished researchers to provide learners with cutting edge information to make the study of adolescence understandable and applicable in practical settings.» —Gary L. Hopkins, MD, DrPH, associate research professor and director, Center for Prevention Research, and director, Center for Media Impact Research, Andrews University «This textbook presents an excellent balance in weighing the evidence from the risk and the resilience literature, incorporating research in racially and ethnically diverse populations.» —Renée R. Jenkins, MD, FAAP, professor, Department of Pediatrics and Child Health, Howard University College of Medicine "This is an engaging, thorough, and thought-provoking statement of our knowledge about adolescence. " —Wendy Baldwin, PhD, director, Poverty, Gender, and Youth Program, Population Council

Veterinary Ophthalmology, Fifth Edition is a fully updated version of the gold-standard reference for diseases and treatment of the animal eye in veterinary medicine. With an internationally renowned list of contributing authors, the book has been revised and expanded to incorporate the most up-to-date research and information. New chapters cover ophthalmic genetics and DNA tests, microsurgery, photography, camelid ophthalmology, and rabbit ophthalmology, and existing chapters feature expanded coverage of noninvasive imaging techniques, feline ophthalmology, equine ophthalmology, and marine mammals and penguins. The book retains its classic structure, with sections on basic vision sciences, the foundations of clinical ophthalmology, canine ophthalmology, and special ophthalmology, which encompasses specific coverage of most commonly treated species and chapters on neuro-ophthalmology and systemic diseases. A companion website offers the images from the book available for download in PowerPoint and the references linked to CrossRef. Veterinary Ophthalmology remains the most comprehensive resource for authoritative information on veterinary ophthalmology worldwide and is a key reference for anyone interested in veterinary or comparative ophthalmology.

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Ultrasonic Periodontal Debridement: Theory and Technique is the first textbook to focus exclusively on this fundamentally important component of periodontal therapy. George, Donley, and Preshaw provide a comprehensive resource for dental students, dental hygiene and therapy students, and periodontal residents, as well as practicing dental hygienists and dentists who are looking to increase their familiarity and skills with ultrasonic instrumentation. The opening section describes the basic foundational knowledge of periodontal debridement; how it differs from and supersedes scaling and root planing, how it fits with modern concepts of periodontal disease pathogenesis, and includes a comparison of periodontal debridement instrumentation modalities. Section 2 describes ultrasonic technology, the variety of tip designs that are available, and provides practical guidance in appropriate tip selection. Section 3 focuses on the clinical applications of ultrasonic periodontal debridement, including patient assessment, medical and dental considerations, and provides specific guidance in clinical debridement techniques. Included are technique modules for each quadrant as well as case studies using real-world examples of situations likely to be encountered in everyday clinical practice, including ultrasonic instrumentation around dental implants.

This unique book will help psychiatrists to understand better the risks of cardiovascular illness and cardiologists to appreciate possible pathophysiological links with psychiatric conditions. It describes the common psychiatric conditions, their key features and how they may influence cardiovascular disease, outcomes, and quality of life. It also considers the cardiovascular complications that may arise as a result of mental illness. In an exciting, collaborative approach, psychiatrists and cardiologists combine their expertise throughout the book to provide guidance on the best way to manage such patients, considering the patient as a whole, not the individual conditions.

This is one of the first books to provide a clinically focussed account of the diagnosis, prevention and treatment of all forms of toothwear. Bringing together the latest research, it is compiled by international leaders in the field to create an essential clinical guide for dental practitioners. The book covers all forms of toothwear and dental erosion, and is presented in a practical format that allows for ease of reference and helps assimilate clinical information quickly. It defines the stages of toothwear, provides schematic approaches to allow better understanding of the key role that saliva plays, and highlights the differences between acid erosion and dental caries. Importantly for clinicians, it provides a framework for developing best practice management strategies by discussing diagnostic skills, treatment planning and therapeutic modalities. An essential resource based on a solid research platform, this book will provide dental clinical professionals with the missing links they seek to diagnose, prevent, manage, restore and rehabilitate the worn dentition more confidently. It will be of value to dentists, dental therapists, dental hygienists, and students in these areas. KEY FEATURES • Covers all forms of toothwear and dental erosion across all age-groups • Includes discussion of best practice management strategies • Discusses aetiology, diagnosis, prevention and treatment in a clinical context • Contains many full colour clinical illustrations and schematic conceptualisations • Brings together the latest clinical views and research with a wide range of international contributors

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

The new edition of Prevention Is Primary provides models, methods, and approaches for building health and equity in communities. This comprehensive book includes the theory, concepts, and models needed to harness social justice and practice primary prevention of unnecessary illness and injury. Ideal for students as well as practitioners, this thoroughly revised and updated second edition combines an overview of advances in the field with effective approaches in the current economic and health care climate. With contributions from noted experts, Prevention Is Primary shows practical applications of intervention science to social and health problems and issues facing at-risk and vulnerable groups. The book describes the overarching framework and principles guiding prevention efforts, including a focus on social justice and health equity, and community resilience. It explores the transition from prevention theory to implementation and practice and from interdisciplinary collaboration to evaluation. Highlighting the book's usefulness as a teaching and learning tool, Prevention Is Primary has real world examples, learning objectives, and review questions for each chapter.

The work of French Philosopher Luce Irigaray has exerted a profound influence on feminist thinking of recent decades and provides a far-reaching challenge to western philosophy's entrenched patriarchal norms. This book guides the reader through Irigaray's critical and creative transformation of western thought. Through detailed analysis of her most important text, Speculum of the Other Woman, Rachel Jones carefully examines Irigaray's transformative readings of such icons of the western tradition as Plato, Descartes, Kant and Hegel. She shows that these readings underpin Irigaray's claim that western philosophy has been dependent on the forgetting of both sexual difference and of our singular beginnings in birth. In response, Irigaray seeks to recover a positive account of sexual difference which would release woman from her traditional position as the 'other' of the subject and allow her to speak as a subject in her own right. In a sensitive reading of Irigaray's work, Jones shows why this distinctively feminist project necessarily involves the transformation of the fundamental terms of western metaphysics. By foregrounding Irigaray's approach to questions of otherness and alterity, she concludes that, for Irigaray, cultivating an ethics of sexuate difference is the condition of ethical relations in general. Lucidly and persuasively written, this book will be an invaluable resource for students and scholars seeking to understand Irigaray's original contribution to philosophical and feminist thought.

Depressive disorders have profound social and economic consequences, owing to the suffering and disability they cause. They often occur together with somatic illness which worsens the prognosis of both. Prevention, detection and optimal treatment of these disorders are therefore of great clinical and economic importance. This edition of the first title in the acclaimed Evidence & Experience series from the World Psychiatric Association has been fully revised and features a new section on depression in primary care – the main channel for the management of these disorders in countries around the world. The format remains a systematic review of each topic, evaluating published evidence, complemented by up to six commentaries in which experts provide valuable insight gained from clinical experience. All the evidence, systematically reviewed and analysed, in one place. Practical context imparted in expert commentaries from around the world, which were highly popular in the previous edition. Provides an unbiased and reliable reference source for practising psychiatrists and physicians everywhere. Features a new section on the treatment of depression in primary care. Edited by a highly experienced, internationally renowned team. This book will be informative and stimulating reading for everyone working with people with depressive disorders in all countries and settings: psychiatrists, psychologists, primary care physicians and other mental healthcare professionals. Review of the first edition “The discussion papers are excellent. I strongly recommend this masterfully edited book, which remarkably succeeds in combining research evidence and clinical experience. It is probably the most helpful update on depression available today, both for the researcher in mood disorders and the practising clinician.” S. Grandi in Psychotherapy and Psychosomatics, 2000

Recently, there has been a growing awareness of the multiple interrelationships between depression and cancer. Depression and Cancer is devoted to the interaction between these disorders. The book examines various aspects of this comorbidity and describes how the negative consequences of depression in cancer could be avoided or ameliorated, given that effective depression treatments for cancer patients are available. Renowned psychiatrists and oncologists summarize the latest evidence on the epidemiology, pathogenesis, screening and recognition, and cultural and public health implications of depression in persons with cancer, among other topics.

Evidence-Based Orthodontics satisfies the educational demands of orthodontics, which demands the integration of the best research evidence with the clinician’s expertise and the patient’s unique values and circumstances. This land-mark text is the first to be devoted to the methodology, principles and practice of evidence-based practice in orthodontics. It aims to serve as a reference for those wishing to understand the principles of evidence-based practice including the foundation for clinical study design, epidemiology and the statistical inferences from data. The ability to define a search strategy from established databases and to identify relevant clinical and translational research in the scientific published literature requires a new approach in orthodontic education. Evidence-Based Orthodontics provides a contemporary approach to those strategies in clinical orthodontic practice. The growing ability to translate critical appraisals of evidence into clinical practice and evaluate clinical evidence for its validity and potential usefulness requires an understanding of basic elements in epidemiology and biostatistics. Evidence-Based Orthodontics provides its readers with a cogent, clear resource with which to navigate and understand this important subject area. It provides students and practitioners of orthodontics with an indispensible guide to this vital tenet of education, research, and clinical practice.