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Biological Mechanisms of Tooth Movement, Second Edition is an authoritative reference to the scientific foundations underpinning clinical orthodontics. Led by an expert editor team and with contributions from an international group of contributors, the book covers key topics including bone biology, the effects of mechanical loading on tissues and cells, genetics, inflammation, tissue remodeling and the effects of diet, drugs, and systemic diseases. Highly-illustrated throughout, this second edition has been fully revised, updated and expanded to new developments in genomics, rapid orthodontics and current controversies in tooth movement research. Trainees, qualified specialists and researchers in orthodontics can rely on this comprehensive text to inform them about the clinical and scientific implications of the biological mechanisms involved in the movement of teeth.

The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.

Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.

The long-term success of periodontal therapy is dependent on proper diagnosis and removal of subgingival tooth-borne accretions in the form of calculus and bacteria. From a clinical perspective, better visualization during the diagnostic and therapeutic phases has been shown to yield better results compared to traditional approaches. Minimally Invasive Periodontal Therapy evaluates the advantages of using minimal invasive techniques, the technologies available for enhancing visualization during minimally invasive therapy, and step-by-step illustrates the clinical use of each technique. Each chapter addresses the advantages and disadvantages of minimally invasive therapies, rationale for the approach, and the advantages and limitations of each of the current methods of improving visualization. The chapters then provide an evidence-based review of the technologies and procedures, and end with case studies for each visualization procedure, featuring clinical photographs.

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Anesthetic complications, which range from simple annoyances to patient mortality, are inevitable, given the many and complex interactions of doctor, patient, personnel, and facility. Anesthesia Complications in the Dental Office helps dentists minimize the frequency and severity of adverse events by providing concise and clinically relevant information that can be put to everyday use. Anesthesia Complications in the Dental Office presents the most up-to-date information on treating anesthesia complications and medical emergencies. Drs. Bosack and Lieblich and a team of expert contributors discuss patient risk assessment; considerations for special needs and medically compromised patients; routinely administered anesthetic agents; adversities that can arise before, during, and after administration of anesthesia; and emergency drugs and equipment. A must-have reference for every dental office.

Unilateral posterior crossbite is a problem often seen in orthodontic practice, and properly understanding chewing patterns will lead to the most effective treatment program. Drawing on their research and available literature, Drs. Piancino and Kyrkanides present a fascinating look at chewing cycles and their role in the functional treatment of unilateral posterior crossbite. Describes the physiology and pathology of chewing patterns and muscular activation in humans Explains chewing patterns and muscular coordination, and their influence on the growth and harmony of the stomatognathic system Clinical instruction for checking and correcting masticatory function and functional asymmetry in order to prevent the relapse of the malocclusion Clinical cases walk readers through the treatment of seven crossbites

Atlas of Orthodontic Case Reviews offers a comprehensive resource to the treatment of orthodontic malocclusions with a case-based approach. Discusses and illustrates the treatment of orthodontic malocclusions using actual clinical cases Presents more than 800 clinical photographs showing the stages of each treatment, to act as a visual reference Includes a description of each malocclusion, an explanation of the desired treatment outcomes, an account of the changes, and review questions for each case

A global perspective on the management and prevention of emerging and re-emerging diseases Emerging infectious diseases are newly identified or otherwise previously unknown infections that cause public health challenges. Re-emerging infectious diseases are due to both the reappearance of and an increase in the number of infections from a disease that is known, but which had formerly caused so few infections that it was no longer considered a public health problem. The factors that cause the emergence or re-emergence of a disease are diverse. This book takes a look at the world's emerging and re-emerging diseases. It covers the diagnosis, therapy, prevention, and control of a variety of individual diseases, and examines the social and behavioral issues that could contribute to epidemics. Each chapter focuses on an individual disease and provides scientific background and social history as well as the current basics of infection, epidemiology, and control. Emerging Epidemics: Management and Control offers five topics of coverage: FUNDAMENTALS Epidemics fundamentals Disasters and epidemics Biosafety RE-EMERGING EPIDEMICS Tuberculosis Plague NEWLY EMERGING EPIDEMICS Leptospirosis Dengue Japanese Encephalitis Chikungunya Fever West Nile Virus Chandipura Virus Encephalitis Kyasanur Forest Disease Hantavirus Human, Avian, and Swine Influenza Severe Acute Respiratory Syndrome Nipah Virus Paragonimiasis Melioidosis POTENTIAL EPIDEMICS Biowarfare and bioterrorism Food contamination and food terrorism Antimicrobial resistance VECTOR CONTROL METHODS Mosquito control Other disease vectors and their control Offering an integrated, worldwide overview of the complexity of the epidemiology of infections, Emerging Epidemics will be a valuable resource for students, physicians, and scientists working in veterinary, medical, and the pharmaceutical sciences.

Infectious diseases constitute a major portion of illnesses worldwide, and microbiology is a main pillar of clinical infectious disease practice. Knowledge of viruses, bacteria, fungi, and parasites is integral to practice in clinical infectious disease. Practical Medical Microbiology is an invaluable reference for medical microbiology instructors. Drs. Berkowitz and Jerris are experienced teachers in the fields of infectious diseases and microbiology respectively, and provide expert insight into microorganisms that affect patients, how organisms are related to each other, and how they are isolated and identified in the microbiology laboratory. The text also is designed to provide clinicians the knowledge they need to facilitate communication with the microbiologist in their laboratory. The text takes a systematic approach to medical microbiology, describing taxonomy of human pathogens and consideration of organisms within specific taxonomic groups. The text tackles main clinical infections caused by different organisms, and supplements these descriptions with clinical case studies, in order to demonstrate the effects of various organisms. Practical Medical Microbiology is an invaluable resource for students, teachers, and researchers studying clinical microbiology, medical microbiology, infectious diseases, and virology.

Salivary Gland Pathology: Diagnosis and Management, Second Edition, updates the landmark text in this important discipline within oral and maxillofacial surgery, otolaryngology/head and neck surgery, and general surgery. Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis, and treatment of all types of salivary gland pathology. Clear and comprehensive, Salivary Gland Pathology: Diagnosis and Management offers complete explanation of all points, supported by a wealth of clinical and surgical illustrations to allow the reader to gain insight into every facet of each pathologic entity and its diagnosis and treatment. Salivary Gland Pathology: Diagnosis and Management offers comprehensive coverage of all aspects of this topic. Beginning with the embryology, anatomy and physiology of the salivary glands, the first section of the book discusses radiographic imaging, infections, cystic conditions, sialoadenitis and sialolithiasis, and systemic diseases. The second section of the book is devoted to the classification of salivary gland tumors and devotes individual chapters to the discussion of each type. Additions for this section of the second edition include molecular biology of salivary gland neoplasia, radiation therapy, and chemotherapy and targeted therapy for salivary gland malignancies. The book closes with a discussion of pediatric salivary gland pathology, traumatic injuries of the salivary glands and miscellaneous pathologic processes of the salivary glands and ducts, including a section on saliva as a diagnostic fluid. The book is intended for a very diverse audience, including academic oral and maxillofacial surgeons, otolaryngologists / head and neck surgeons, general surgeons, as well as residents in these disciplines. Private practitioners will want to place this publication on the bookshelves of their offices so as to consult the textbook when evaluating a patient with salivary gland pathology.

A concise, pocket-sized, A-Z rapid reference handbook on all the essential areas of mental health nursing, aimed at nursing students and newly qualified practitioners. Covers a broad range of mental health disorders, approaches interventions and conditions Easy to locate practical information quickly in a pocket sized, rapid reference format The topics and structure are mapped on to the NMC’s (2010) Standards for Pre-registration Nursing Education and their required essential skills and knowledge.