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Overactive Bladder: Practical Management provides urologists, gynecologists and other health practitioners with a comprehensive clinical guide to this very common problem, resulting in a perfect resource to consult time and time again. Beginning with an introductory section covering the definition and pathophysiolgy of OAB, it then moves on to cover evaluation, first-line management, second-line management and finally surgery. Well-illustrated throughout, each chapter begins with a key points box outlining the most important take-home messages. Also included are clear management algorithms to aid decision-making, 'Do's and Don't' boxes to help avoid errors made, key references to the top journal articles, and the very latest guidelines from the EAU, AUA and other major urology societies. Chapters are written by the top names in the field and the entire book is expertly edited by Jacques Corcos, John Heesakkers and Scott MacDiarmid. The result is a consistent, comprehensive and fully up to date approach to OAB, providing urologists managing patients with this condition with rapid access, specialist clinical guidance.

Zoonotic Tuberculosis: Mycobacterium bovis and Other Pathogenic Mycobacteria, Third Edition is a comprehensive review of the state of the art in the control and elimination of infections caused by Mycobacterium tuberculosis complex in animals and humans. This update to the most complete and current reference available on Mycobacterium bovis includes new coverage of the latest molecular techniques; more information on human infection and One Health; updates to the information on the International Union Against Tuberculosis and Lung Disease (IUATLD), the World Health Organization (WHO), Pan American Health Organization (PAHO), and the United States Department of Agriculture’s (USDA) National Tuberculosis Eradication Program; and coverage of additional African countries. The Third Edition upholds the book’s reputation as a truly global resource on M. bovis. Written by an international list of tuberculosis experts, chapters cover the status of tuberculosis in many regions throughout the world and deal with issues related to the detection, spread, and control of Mycobacterium bovis, as well as the economic impact of outbreaks. Zoonotic Tuberculosis: Mycobacterium bovis and Other Pathogenic Mycobacteria offers valuable information for public health officials, medical doctors, state and federal regulatory veterinarians, veterinary practitioners, and animal caretakers.

Natural Products: Discourse, Diversity and Design provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged. Natural Products addresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contributions from researchers at top labs around the world, Natural Products is unprecedented in its combination of disciplines and the breadth of its coverage. Natural Produces: Discourse, Diversity and Design will appeal to advanced students and experienced researchers, from academia to industry, in diverse areas including ecology, industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry.

The publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee’s tradition, Hendee’s Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-and machine-related data has necessitated an increased awareness of the role of informatics in radiation therapy. As such, this edition reflects the huge advances made over the last ten years. This book: Provides state of the art content throughout Contains four brand new chapters; image-guided therapy, proton radiation therapy, radiation therapy informatics, and quality and safety improvement Fully revised and expanded imaging chapter discusses the increased role of digital imaging and computed tomography (CT) simulation The chapter on quality and safety contains content in support of new residency training requirements Includes problem and answer sets for self-test This edition is essential reading for radiation oncologists in training, students of medical physics, medical dosimetry, and anyone interested in radiation therapy physics, quality, and safety.

Pediatric Urology: Surgical Complications and Management, 2nd edition focuses 100% on the most common problems that can occur during pediatric urologic surgery, and how best to resolve them, ensuring the best possible outcome for the patient. As well as being thoroughly revised with the latest in management guidelines, brand new to this edition are a host of clinical case studies highlighting real-life problems during urologic surgery and the tips and tricks used by the surgeon to resolve issues faced. These will be invaluable for urology trainees learning their trade as well as for those preparing for Board or other specialty exams. Chapters will include problem solving sections as well as key take-home points. In addition, high-quality teaching videos showing urologic surgery in action will be included via the companion website – again proving an invaluable tool for all those seeking to improve their surgical skills. Edited by an experienced and international trio of urologists, they will recruit the world’s leading experts, resulting in a uniform, high-quality and evidence-based approach to the topic. Pediatric Urology: Surgical Complications and Management, 2nd edition is essential reading for all urologists, especially those specialising in pediatric urology and urologic surgery, as well as general surgeons.

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

What types of mental health care are right for the 21st century—in all countries, around the world? What is the best balance of primary care and specialist mental health care for people with mental illness? What is the best evidence for effective treatments and services? Which methods are most suitable for answering these questions? These are the tough issues addressed by this book. Leading experts from across the world bring their experience to bear in a series of chapters that set out the very best evidence in this field. They present clear accounts of what is known, extensively referenced, with critical appraisals of the strength of the evidence and the robustness of the conclusions that can be drawn. This book was inspired by the work of Michele Tansella on the development of community care globally. It comprises four sections, identifying the challenges associated with providing mental health services in high-, middle- and low-income countries, then describing ways to meet these challenges. A section on new research methods to produce practical evidence is a novel aspect of the book. The final section addresses how best to deliver new forms of care, bearing in mind the human resources available. The chapters extensively cite specific studies to enhance the practical relevance. Much of the cited research involves service users so their voice is heard throughout the text. Mental health is rapidly becoming recognised as one of the leading global health challenges. This book adds to our knowledge of the challenge and the solutions and stands to make a significant contribution to global mental health.

Pathology of Small Mammal Pets presents a ready reference for veterinarians, veterinary pathologists, and technicians who work with small mammal companion animals. Provides up-to-date, practical information on common disease conditions in small mammal companion animals Offers chapters logically organized by species, with comprehensive information on diagnosing diseases in each species Takes a practical, system-based approach to individual disease conditions Covers clinical signs, laboratory diagnostics, gross pathology, histopathology, and differential diagnoses in detail Includes relevant information for conventional breeding operations and breeding facilities, with strategies for disease management in herds and colonies Features information on normal anatomy in included species to assist in recognizing pathology

Practical Procedures in Aesthetic Dentistry presents a comprehensive collection of videos demonstrating clinical techniques in aesthetic and restorative dentistry, and is accompanied by a handbook summarising the key points of each procedure. Interactive website hosting over nine hours of video Accompanying illustrated handbook summarising key points Expert teaching across a comprehensive range of aesthetic and restorative procedures International team of contributors with clinical and academic expertise

The first comprehensive, authoritative review of one of the most fundamental and important issues in infection control and patient safety, hand hygiene. Developed and presented by the world's leading scholar-clinicians, Hand Hygiene is an essential resource for all medical professionals. Developed and presented by the world leaders in this fundamental topic Fully integrates World Health Organization (WHO) guidelines and policies Offers a global perspective in tackling hand hygiene issues in developed and developing countries Coverage of basic and highly complex clinical applications of hand hygiene practices Includes novel and unusual aspects and issues in hand hygiene such as religious and cultural aspects and patient participation Offers guidance at the individual, institutional, and organizational levels for national and worldwide hygiene promotion campaigns

Ethnic Dermatology Principles and Practice Edited by Ophelia E. Dadzie, MB BS, MRCP, Centre for Clinical Science and Technology, University College London, Division of Medicine, Whittington Hospital Campus, London, UK Antoine Petit, MD, Department of Dermatology, Hôpital Saint-Louis, Paris, France Andrew F. Alexis, MD, FAAD, Director Skin of Color Center, Department of Dermatology, St Luke’s-Roosevelt Hospital Center, New York, NY, USA Richly pigmented skin is the most common skin type internationally Historically, dermatology has focused on white skin. But rich pigmentation can lead to differences in presentation, disease course and outcome, and reaction to treatment. Some dermatologic conditions are seen predominantly or only in richly pigmented skin. Ethnic Dermatology: Principles and Practice provides a practical approach to the dermatology of non-white skin. Written from a global perspective to include Asian, African-Caribbean and North African skin types, it covers all the bases of dermatology including: Grading scales in dermatologic disease Pediatric dermatology Dermatology and systemic disease Drug eruptions Hair and scalp disorders Cosmetic dermatology With a central focus on practical action from an international cast of authors, Ethnic Dermatology: Principles and Practice gives you the clinical tools you need when skin colour matters.

This book addresses the difficulties experienced by wet lab researchers with the statistical analysis of molecular biology related data. The authors explain how to use R and Bioconductor for the analysis of experimental data in the field of molecular biology. The content is based upon two university courses for bioinformatics and experimental biology students (Biological Data Analysis with R and High-throughput Data Analysis with R). The material is divided into chapters based upon the experimental methods used in the laboratories. Key features include: • Broad appeal–the authors target their material to researchers in several levels, ensuring that the basics are always covered. • First book to explain how to use R and Bioconductor for the analysis of several types of experimental data in the field of molecular biology. • Focuses on R and Bioconductor, which are widely used for data analysis. One great benefit of R and Bioconductor is that there is a vast user community and very active discussion in place, in addition to the practice of sharing codes. Further, R is the platform for implementing new analysis approaches, therefore novel methods are available early for R users.