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Clinical Endocrinology of Companion Animals offers fast access to clinically relevant information on managing the patient with endocrine disease. Written by leading experts in veterinary endocrinology, each chapter takes the same structure to aid in the rapid retrieval of information, offering information on pathogenesis, signalment, clinical signs, diagnosis, differential diagnosis, treatment, prognosis, and prevention for a broad list of endocrine disorders. Chapters begin with brief summaries for quick reference, then delve into greater detail. With complete coverage of the most common endocrine diseases, the book includes chapters on conditions in dogs, cats, horses, ferrets, reptiles, and other species. Clinical Endocrinology of Companion Animals is a highly practical resource for any veterinarian treating these common diseases.

Emergency Medical Services: Clinical Practice and Systems Oversight is the official textbook of the National Association of EMS Physicians™ (NAEMSP™) National EMS Medical Directors Course and Practicum™. Now paired with a companion website featuring self-assessment exercises, audio and video clips of EMS best practices in action, and more, this essential study aid guides students through the core knowledge they need to successfully complete their training and begin their careers as EMS physicians. Emergency Medical Services: Clinical Practice and Systems Oversight consists of: Volume 1: Clinical Aspects of EMS Volume 2: Medical Oversight of EMS Companion website featuring supportive self-assessment exercises, audio and video clips

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

This is a concise visual guide to the major techniques of regional anesthesia and analgesia for small animal practitioners, with complete coverage of the relevant physics, physiology, and pharmacology. Provides straightforward advice and easy-to-implement strategies for general veterinary practitioners without specialist training who want to incorporate regional anesthesia into their practice Features an accessible design with plenty of diagrams and photos and a convenient and robust spiral-bound format that lays flat for use during procedures Broken into sections which explain techniques by limb or body part and by species Details important anatomy (nerves, bones, and vessels), as well as possible side effects and complications

Cleft Lip and Palate Management: A Comprehensive Atlas—with more than 400 photographs and illustrations—provides the latest concepts about the surgical/orthodontic interrelation in cleft lip and palate treatment. Dr. Bennun and his team detail the diagnostic techniques to determine the best treatment protocols for optimal results and decreased chance of retreatment. The first part explains the principles of cleft and palate treatment, including the role of tissue engineering in craniofacial surgery. Part 2 details the aspects of primary surgical reconstruction, Part 3 discusses orthodontic treatments of cleft lip and palate, including a chapter on adult treatment, and Part 4 covers how to improve results in interdisciplinary treatment. Case presentations include results of treatment after 20-year follow up visits. Ideal for oral and maxillofacial surgeons, pediatric plastic surgeons, orthodontists, pediatric dentists, and residents in these specialties.

A concise and practical quick reference guide to treating reptiles in first opinion veterinary practice Reptile Medicine and Surgery in Clinical Practice is the ideal guide for the busy veterinarian treating reptile cases. Designed as a quick reference guide, but with comprehensive coverage of all the topics needed for first opinion practice, the book presents the principles of reptile medicine and surgery. Richly illustrated chapters cover anatomy, physiology, behaviour, husbandry, reproduction, common diseases and disorders, and much more. Application in a clinical setting is emphasized throughout, including guidance on the physical examination, diagnostic testing and imaging, treatment options, and anaesthetic and surgical techniques. Practical quick-reference guide—ideal for the busy, first-opinion veterinary practitioner Richly illustrated in full colour throughout Edited by a team of highly experienced exotic animal veterinarians Useful reference for those studying for postgraduate certificates in exotic animal medicine With contributions from experts around the globe, Reptile Medicine and Surgery in Clinical Practice is a valuable reference offering a balanced international view of herpetological medicine.

Epilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day. Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy. Each chapter employs a standard structure providing background, epidemiology, pathophysiology, etiology, diagnosis, treatment, prognosis and further practical advice. From an international team of expert editors and contributors, Epilepsy and the Interictal State is a valuable resource for specialist epileptologists and neurologists, as well as for neurosurgeons, neurology nurses, psychiatrists, family physicians and general practitioners.

This comprehensive introduction to computational network theory as a branch of network theory builds on the understanding that such networks are a tool to derive or verify hypotheses by applying computational techniques to large scale network data. The highly experienced team of editors and high-profile authors from around the world present and explain a number of methods that are representative of computational network theory, derived from graph theory, as well as computational and statistical techniques. With its coherent structure and homogenous style, this reference is equally suitable for courses on computational networks.

A truly interdisciplinary approach to this core subject within Forensic Science Combines essential theory with practical crime scene work Includes case studies Applicable to all time periods so has relevance for conventional archaeology, prehistory and anthropology Combines points of view from both established practitioners and young researchers to ensure relevance

By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a comprehensive survey ranging from small-molecule antibiotics to antimicrobial peptides and their engineered mimetics, from enzymes to nucleic acid therapeutics, from metallic nanoparticles to photo- and sonosensitizers and to phage therapy. In each case, the therapeutic approaches are compared in terms of their mechanisms, likelihood to induce resistance, and their efficiency in a global healthcare context. Unrivaled knowledge for professionals in fundamental research, pharmaceutical development and clinical practice.

Most books on hematopathology are neoplastic in scope and offer little non-neoplastic content. In Non-Neoplastic Hematopathology and Infections, the authors fully describe the hematologic manifestations in tissue and blood of infectious agents, including many rare and exotic diseases found in both Western and Eastern hemispheres, in order to assist pathologists and medical laboratory professionals all over the world in better diagnosing and treating such infections. Thoroughly illustrated with photographs, tables and text, this book features a wide range of non-neoplastic hematologic disorders, as well as reactive patterns of non-infectious and infectious agents. Comprehensive and state-of-the-art diagnostic materials are described, as are the epidemiology, pathobiology, clinical and pathologic manifestations in blood and lymphatic organs—as well as the approaches to treatment. In addition, Non-Neoplastic Hematopathology and Infections: Contains detailed information on the pathology and patterns of blood, lymph node, and a number of bone marrow and splenic infections and infectious agent manifestations Thoroughly updates the classic pathology of reactive lymphadenopathies and extends this pattern-based approach to tropical and emergent infections Promotes the multidisciplinary integration of hematopathologists and microbiologists in the analysis and diagnostic work-up of tissue and blood Complements current major treatises on such tropical diseases as Manson's, Ashworth's, and Doerr's and updates the classic tomes of William St. Clair Symmers and current texts on neoplastic hematopathology Non-Neoplastic Hematopathology and Infections is an important book for any medical professional interested in non-neoplastic hematology, infections and tissue hematopathology, infectious diseases and tropical medicine, and tropical hematopathology.