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This book showcases the development and evaluation of innovative examples of pain management initiatives by advanced practitioners. It considers each service development or community initiative both in terms of advanced practice nursing and pain management. There is a wide range of examples of innovation in pain management included – from the introduction of ketamine use in one trust, to wider issues around meeting the needs of pain management in the community. The book considers issues including use of research, education and interprofessional working in the advanced practitioner role. Each chapter looks at development of the service, challenges of implementation, evaluation of the service’s success and justifying the importance of the advanced nurse in the service’s achievements. Underlying theory is considered but the focus of each chapter is the translation of knowledge and skills into practice Written by expert advanced nurse practitioners with a wealth of experience in pain management Explores pain management in primary and secondary care, both within and outside the NHS Suitable for qualified nurses, Nurse Practitioners, specialist nurses working in the pain field and nursing students on postgraduate courses on pain management

Meeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron The new edition is a key reference source for all those involved in the practice of blood management and conservation.

For over 50 years covering 10 previous editions, Schiff's Diseases of the Liver has provided hepatologists with an outstanding evidence-based clinical reference work covering all aspects of liver disease, and is without doubt one of the world’s leading hepatology textbooks. Now fully revised and updated, it will serve as your first-stop reference for today’s demanding clinical situations. With a strong clinical focus, Schiff’s Diseases of the Liver covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs, before moving on to sections that address specific diseases and clinical syndromes. Its enormous appeal has been due to the clarity of text, combined with the sheer thoroughness of its breadth of content. Key features include: An attractive full color design throughout Informative section overviews for each section Concise key concepts box in every chapter Treatment guidelines and management algorithms for every disease A full liver transplant section This 11th edition sees all existing chapters fully revised and refreshed with the very latest in clinical information from the world’s leading hepatologists. Also new to this edition is a companion website containing a variety of important extra materials, including: Approximately 100 multiple choice questions of the standard used in ABIM board exams in gastroenterology, to allow the user to self-assess their clinical knowledge All 450+ figures from the book in a high-quality, fully transportable and downloadable electronic format High-quality video clips of a variety of surgical procedures, all fully linked to the text 35 case studies featuring real-life clinical scenarios. Schiff’s Diseases of the Liver remains the key textbook for all gastroenterologists and hepatologists, in training or fully qualified, managing patients with liver disease.

Zoo Animal and Wildlife Immobilization and Anesthesia, Second Edition is a fully updated and revised version of the first comprehensive reference on anesthetic techniques in captive and free-ranging wildlife. Now including expanded coverage of avian and aquatic species, this exhaustive resource presents information on the full range of zoo and wildlife species. Covering topics ranging from monitoring and field anesthesia to CPR and euthanasia, the heart of the book is devoted to 53 species-specific chapters providing a wealth of information on little-known and common zoo and wildlife animals alike. In addition to new species chapters, the new edition brings a new focus on pain management, including chronic pain, and more information on species-specific physiology. Chapters on airway management, monitoring, emergency therapeutics, and field procedures are all significantly expanded as well. This update to Zoo Animal and Wildlife Immobilization and Anesthesia is an invaluable addition to the library of all zoo and wildlife veterinarians.

Health protection professionals need rapid access to authoritative and easy-to-use information to ensure their actions are based on international best practice. This is precisely what the Communicable Disease Control and Health Protection Handbook does. This concise and practical handbook is an essential guide for all those who have responsibility for the identification and control of infectious disease. In the past five years, there have been many major changes in health protection practice, and significant scientific progress in the field, all of which are reflected in this new edition of the popular Communicable Disease Control and Health Protection Handbook. All chapters have been updated in line with recent changes in epidemiology, new guidelines for control and administrative changes. Basic principles of communicable disease control and health protection, major syndromes, control of individual infections, main services and activities, organizational arrangements for all EU countries and sources of further information are covered. A new chapter on pandemic planning has been included, and the influenza chapter has been expanded to cover seasonal, avian and pandemic flu. Communicable Disease Control and Health Protection Handbook is an indispensible companion for all those who are engaged in health protection, including public health physicians, epidemiologists, infection control nurses, microbiologists and trainees in the field.

Extraordinary advances in the understanding of the links between nutrition, metabolism, and cardiovascular disease have prompted a systematic reappraisal of knowledge in the field. As a result, it is now imperative that clinicians who care for patients with CVD or its key risk factors have a solid understanding of the often complex interrelationships between cardiovascular health and chronic diseases such as diabetes and obesity. Written by a team of international thought leaders in cardiology, endocrinology, diabetology and nutritional science, this important new book: Examines and updates the role of obesity, hyperlipidemia, diabetes, hypertension, thrombosis, and aging in atherogenesis Describes in detail the scientific and clinical evidence of the etiopathogenesis of ischemic heart disease as well as of peripheral and cerebrovascular disease Focuses on the 6 topics that will be of greatest interest to readers: 1) general nutrition, 2) metabolic syndrome and diabetes, 3) hyperlipidemia and atherosclerosis, 4) hypertension and cerebrovascular disease, 5) hemostasis and thrombosis, 6) aging Throughout the book, in clear and accessible text, contributors illuminate the close relationship between dietary habits, the metabolic processes of nutrients, and their impact on the cardiovascular system, always with an eye on how the physician can use this information to implement better cardiovascular prevention and improve patient care. Nutritional and Metabolic Bases of Cardiovascular Disease is ideal for those who need to update their knowledge of the links between nutrition, metabolism and CVD, from trainees, clinicians and clinical investigators in cardiovascular medicine to endocrinologists, diabetologists, and nutritionists.

Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

This handbook and ready reference presents a combination of statistical, information-theoretic, and data analysis methods to meet the challenge of designing empirical models involving molecular descriptors within bioinformatics. The topics range from investigating information processing in chemical and biological networks to studying statistical and information-theoretic techniques for analyzing chemical structures to employing data analysis and machine learning techniques for QSAR/QSPR. The high-profile international author and editor team ensures excellent coverage of the topic, making this a must-have for everyone working in chemoinformatics and structure-oriented drug design.

Improve your skills in visual diagnosis Speed and accuracy of diagnosis is the key to saving lives in emergency and critical care medicine. Careful visual inspection of the patient, the data (radiography, electrocardiogram), and related clues can often help providers choose the right diagnosis and ultimately the best treatment – but this knowledge comes with experience. This book provides 110 randomly presented visual diagnosis cases for self-testing, imitating real-life situations found in the emergency department setting. Written by distinguished emergency and critical care physicians, and thoroughly revised and updated throughout, this second edition includes 25% new cases and is an ideal aid for trainees preparing for Board examinations as well as an invaluable ‘refresher’ for qualified emergency and critical care providers. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

Focusing on 'day one competencies', this book offers essential guidance to the most common problems encountered in small animal general practice. Addressing 100 core scenarios, it is ideal for the undergraduate or newly qualified vet, and for those seeking an up-to-date refresher. Organized by presenting sign (diarrhoea, itching) or disease (diabetes mellitus, pancreatitis), and with colour illustration throughout, each chapter explains: how to make a diagnosis which interventions are most appropriate in general practice what the vet should say to the client before and after examination The authors also offer invaluable advice on other key topics such as annual health checks, neutering and euthanasia, and they tackle the tough questions: What if it doesn't get better? What is the low cost option? When should I refer? Never before has so much practical information been brought together in a single volume. Like having an experienced or specialist clinician standing by your side in the consulting room, 100 Top Consultations will become a trusted companion for students and practitioners alike.

Exercise Therapy in the Management of Musculoskeletal Disorders covers the fundamentals of using exercise as a treatment modality across a broad range of pathologies including osteoarthritis, inflammatory arthropathies and osteoporosis. As well as offering a comprehensive overview of the role of exercise therapy, the book evaluates the evidence and puts it to work with practical ideas for the management of musculoskeletal disorders in different areas of the body, for differing pathologies and for a range of patients. Part 1 introduces the reader tothe role of exercise in managing musculoskeletal disorders and covers measurement and assessment. Part 2 looks at the regional application of exercise therapy with chapters on areas of the body such as the cervical spine, the shoulder complex and the knee. Part 3 examines specific populations: the developing child, the cardiac and respiratory patient, obesity and osteoporosis. Exercise Therapy in the Management of Musculoskeletal Disorders is an invaluable resource for student physiotherapists as well as clinicians designing rehabilitation programmes for their patients. KEY FEATURES Concise and comprehensive Team of expert contributors Offers practical guidance Evaluates the evidence

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials. The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future. Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, Critical Pathways to Success in CNS Drug Developmentis full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations