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Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach. From the contents: * Prediction of intra- and inter-species protein-protein interactions facilitating systems biology studies * Modulators of protein-protein interactions: The importance of Three-Dimensionality * Interactive technologies for leveraging the known chemistry of anchor residues * SH3 Domains as Drug Targets * P53 MDM2 Antagonists: Towards Non Genotoxic Anticancer Treatments * Inhibition of LFA-1/ICAM interaction for treatment of autoimmune diseases * The PIF-binding pocket of AGC kinases * Peptidic inhibitors of protein-protein interactions for cell adhesion receptors * The REPLACE Strategy for generating Non-ATP competitive Inhibitors of Cell-Cycle Protein Kinases and more

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Are you about to sit your pharmacology exams? Do you lack confidence in prescribing? Would it help to have a quick reference, pocket-sized reassurance on common drugs and the conditions that they are used in? The Hands-on Guide to Clinical Pharmacology is the perfect companion for students, doctors, nurses, pharmacists and other health care professionals who need help on the ward or are preparing for exams. It includes sections containing both treatment regimens of common conditions and detailed information on the relevant drugs that help you obtain a better understanding of therapeutic management. The benefits include: A-Z of over 100 key drugs in a one-drug-per-page format A systems-based approach Fully indexed text Clear explanations of drug mechanisms – a regular feature of pharmacology exams Management guidelines for common conditions within each system Brand new two-colour design to help with information retrieval A new chapter on chemotherapy agents Take the stress out of clinical pharmacology with The Hands-on Guide!

Flow Cytometry of Hematological Malignancies contains an array of graphical outputs produced by the technique in the study of the most (and the least) common diseases. The images included allow you to compare your own results with a third party reference pattern. There is a detailed description of the main leukocyte antigens, together with a description of their distribution amongst normal and abnormal blood cells. The book also provides a comprehensive description of the phenotype of every neoplastic blood disease recorded in the WHO classification system, including all the instructions needed to recognise and classify even the least common entity. Designed to be practical, the book is perfect for quick consultation and is divided into two main sections. Section I deals with the direct object of immunophenotyping, and Section II deals with the ultimate target of the analysis. More than 50 antigens are covered and every antigen is dealt with in three main parts: general features, cytometric features and practical hints. This authoritative and state-of-the-art reference will be invaluable for clinicians directly involved in the diagnosis and analysis of hematological diseases, including hematologists, hematopathologists, oncologists, pathologists and technicians working in diagnostic laboratories.

Endoscopy is the primary diagnostic method for GI complaints and is replete with an ever expanding array of therapeutic capabilities. Successful Training in Gastrointestinal Endoscopy will provide all gastroenterologists with the exact set of skills required to perform endoscopy at the highest level. GI trainees will find it a crucial primer for learning endoscopy; teachers will find it a guide to understand how best to develop the expertise of their students; and experienced practicing gastroenterologists will find it a useful refresher tool to brush up on their existing endoscopic skills and to familiarise themselves with new procedures, including issues of safety and competence while performing them. With contributions from internationally recognized leaders in endoscopy education and an endorsement by the World Organisation of Digestive Endoscopy, each chapter will examine the specific skill sets and procedure related tasks which must be mastered when learning a particular technique, including: Specific descriptions of accessories required Standard training methods for the procedure Optimal utilization of novel learning modalities such as simulators Quality measures and objective parameters for competency Available tools for assessing competency once training has been completed In addition to the 400 high-quality, outstanding colour photos, the book will come with a DVD containing over 130 annotated teaching videos of both actual procedures and ex-vivo animal model simulations. These videos will illustrate, in a step by step fashion the proper techniques to be followed, highlighting clinical pearls from the experts and the most common mistakes to avoid. Successful Training in Gastrointestinal Endoscopy will be a key purchase for all gastroenterologists, whether in training or experienced, to allow them to develop and perfect their endoscopic skills. It will be a particularly useful guide for those interested in mastering the latest new techniques and procedures and an essential reference for teachers of endoscopy and students alike. Note: DVD and other supplementary materials are not included as part of eBook file. These materials are available for download upon purchase.

Written, reviewed, and edited in a collaborative effort by cardiology fellows and faculty of one of the most prestigious academic centers in the country, this concise volume gives cardiology fellows the book they have long needed. Keeping coverage of the underlying pathophysiology and mechanism of disease to a minimum, the authors focus on the diagnosis and treatment of cardiac disorders. Practical and easily accessible at the time of decision making, the book relays important concepts through concise and to-the-point pearls and by utilizing algorithm charts and illustrations.

The Delphi Technique in Nursing and Health Research is a practical guide to using the Delphi methodology for students and researchers in nursing and health. It adopts a logical step-by-step approach, introducing the researcher to the Delphi, outlining its development, analysing key characteristics and parameters for its successful use and exploring its applications in nursing and health. The book addresses issues of methodology, design, framing the research question, sampling, instrumentation, methodological rigour, reliability and validity, and methods of data analysis. The Delphi Technique in Nursing and Health Research enables the reader to be aware of the limitations of the technique and possible solutions, to design a Delphi questionnaire for each of the different rounds of a study, to consider different approaches to the technique in relation to a study, to analyse the data from each round of a Delphi study, and to understand the importance of feedback between rounds. Key Features A practical guide to facilitate use of the Delphi technique Provides the reader with the necessary information to participate in and conduct Delphi studies Examines different types of Delphi, including the e-Delphi, and modifications made to the technique Includes examples of real empirical investigations, brief case scenarios and key learning points for each chapter Explores the role of the Delphi researcher Explores ethical issues and issues of anonymity, use of experts and controlled feedback

Orthodontic Treatment of Impacted Teeth provides its readers with a gold-standard resource to tackle common, complex and multi-factorial clinical scenarios. Rooted firmly in the scientific reality, it also provides a valuable repository of the evidence-base for this subject area. The third edition of this classic text has been fully revised and updated to reflect the latest advances in research and clinical practice. It discusses recent developments in the periodontal outcome of surgical exposure of impacted teeth, and also incorporates more protocols for routine cases. This enables clinicians to develop their skills in the simpler cases, as well as to improve their understanding of complex and rare presentations. An especially useful chapter looks at failure and impending failure, providing a valuable insight into the real life management of impacted teeth. The author describes how to recognize failure and proposes ways to avoid it, frequently illustrating them with cases from his own clinic. KEY FEATURES • Fully revised and updated classic • Coverage expanded to include protocols for routine, as well as complex cases • Includes new chapter on extreme tooth displacement and complicating factors • Provides unparalleled coverage of the evidence base • Highly illustrated in full colour

This book fills an important niche in the market providing practical expert advice on the involvement of service users – patients, carers and the public – in nursing and healthcare research. An invaluable guide for anyone working or involved in nursing and healthcare research, this book provides a step-by-step guide to the principles and process of involvement, including understanding the rationale for involvement, designing involvement, working with service users, and evaluating what has been achieved. With illustrations, worked examples and tool sheets throughout, this evidence-based guide uses real life examples from recent research studies in health and social care research, thus relating theory to practice in a meaningful way. The Handbook of Service User Involvement in Nursing & Healthcare Research introduces a wide range of key issues, including: Why? Why should researchers involve service users? How? How can researchers and service users work together successfully and productively? Who? Who chooses to become involved in research? How are issues of representation and diversity addressed? When? At what stage should service users be involved in the research process?

This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.