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Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

A practical approach to the recognition and management of all aspects of migraine Migraine, characterized by periodic bursts of severe debilitating headache, is increasingly recognized as being not only a disease in its own right, but as a disorder that co-occurs with other disorders. Comorbidity in Migraine presents a clinically-oriented, comprehensive treatment approach to migraine. The international collection of authors cover: Migraine and Psychiatric Disorders Migraine and Vascular disorders Migraine and Epilepsy Migraine and other Pain Disorders Migraine and Medication Overuse Case vignettes and management algorithms enhance the clinical utility of the book.Comorbidity in Migraine enhances your ability to treat your migraine patients effectively to improve their quality of life. Titles of Related Interest Pediatric Headaches in Clinical Practice Hershey, Powers, Winner, Kabbouche (eds); ISBN 978-0-470-51273-9 Handbook of Epilepsy Treatment, 3e Shorvon; ISBN 978-1-4051-9818-9 Neurology: A Queen Square Textbook Clarke, Howard, Rossor, Shorvon (eds); ISBN 978-1-4051-3443-9

Enhancing Human Capacities is the first to review the very latest scientific developments in human enhancement. It is unique in its examination of the ethical and policy implications of these technologies from a broad range of perspectives. Presents a rich range of perspectives on enhancement from world leading ethicists and scientists from Europe and North America The most comprehensive volume yet on the science and ethics of human enhancement Unique in providing a detailed overview of current and expected scientific advances in this area Discusses both general conceptual and ethical issues and concrete questions of policy Includes sections covering all major forms of enhancement: cognitive, affective, physical, and life extension

Venepuncture and cannulation are the most commonly performed invasive procedures in the UK, and are everyday procedures in health care practice. Venepuncture and Cannulation is a practical guide to these procedures. It assumes no prior knowledge and equips nurses and other health professionals with the clinical skills and knowledge they need in order to confidently perform venepuncture and cannulation in both hospital and community settings. Explores relevant anatomy and physiology Covers education and training, as well as legal and ethical issues Considers potential complications, and patient perspectives Provides guidance on the selection of the appropriate vein and equipment, and common blood tests

Patients with breast and gynaecological cancers have to contend with a large number of difficult and challenging issues. To help them to do this it is vital that their health carers are fully informed in all aspects of women's cancers. This book provides a comprehensive and meaningful picture of this oncological area, including epidemiology, histopathology, staging, genetic predisposition, sexual function, fertility, treatment and management, survivorship, and palliative care. To give this book added credibility and holistic application, contributions of women with cancer have been included, and the text is interspersed with patient accounts and experiences. Women's Cancers is essential reading for all nurses and health care professionals working in cancer care settings, as well as patients and families.

In this second edition of the second title in the acclaimed Nutrition Society Textbook Series, Nutrition and Metabolism has been revised and updated to meet the needs of the contemporary student. Groundbreaking in their scope and approach, the titles in the series: Provide students with the required scientific basics of nutrition in the context of a systems and health approach Enable teachers and students to explore the core principles of nutrition, to apply these throughout their training, and to foster critical thinking at all times. Throughout, key areas of knowledge are identified Are fully peer reviewed, to ensure completeness and clarity of content, as well as to ensure that each book takes a global perspective Nutrition and Metabolism is an essential purchase for students of nutrition and dietetics, and also for those students who major in other subjects that have a nutrition component, such as food science, medicine, pharmacy and nursing. Professionals in nutrition, dietetics, food science, medicine, health sciences and many related areas will also find much of great value within its covers.

Cases for PACES provides a concise study aid to Part II of the MRCP examination; the Practical Assessment of Clinical Examination Skills or PACES. The new edition of this very popular study guide has been completely updated, and now includes scenarios for Station 5, introduced in October 2009. Featuring a ‘case study’ format that matches the style of the exam, it includes all the essential information – perfect for on-the-ward revision and study. Written by authors who remember their own PACES examination, their experience in learning and teaching PACES is condensed to provide exactly what you need to know to pass. With its informal style, Cases for PACES is also ideal for self-directed learning in groups, and will help you hone your clinical skills and boost your confidence in the run-up to the examination. For more titles to help you prepare for MRCP examinations go to www.wileymedicaleducation.com

Asthma is a common condition with increasing prevalence. This new edition of the highly regarded ABC of Asthma has been thoroughly revised with reference to the latest British Thoracic Society guidelines on the management of asthma in children and adults. It covers the advances in practice and methods, with a new emphasis on delivery systems, self-dose assessment and delivery of care with different pharmacological approaches. The ABC of Asthma is a concise, up-to-date overview of all aspects of asthma and includes two new chapters focussing on GP practice issues including clinical management and organisation of asthma care. It is ideal for GPs, junior doctors and medical students, nurses, and anyone dealing with the treatment of asthma in children and adults.

Written by a multidisciplinary team of medical and nursing experts, this fully-updated second edition provides evidence-based coverage of all frequently seen neonatal conditions. Divided into chapters based on body-systems, each section includes discussion of relevant embryology, anatomy and physiology. Designed for real-life practice in the ward, each chapter includes clear guidelines for procedure and discussion of best practice. Case studies are used throughout to aid discussion of specific equipment, conditions, and situations. An essential resource for neonatal nursing and midwifery students, as well as practicing neonatal nurses, this acclaimed text may also be of use to junior doctors beginning neonatology. Evidence-based theory clearly linked to application in the ward with case studies throughout Procedure and equipment guidelines included, with specific recommendations for practice Accessible format designed for easy reading and reference Highly illustrated with relevant diagrams and pictures

This book has been written for PACES candidates by a team of authors who are themselves recent PACES candidates. Frustrated by the lack of suitable revision material available, the authors drew upon their own experiences of studying and the exam to create this concise revision aid. Presented in a case study format to match the exam, the book has an informal writing style. The syllabus for the exam has been reviewed extensively by the authors and, whilst ensuring that the book covers all the essential information, obscure cases are not featured. Designed to fit in a white coat pocket for 'on the job' study, the structure of the material guides the reader through self-directed learning.