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Explores the utility and potential of extremophiles in sustainability and biotechnology Many extremophilic bio-products are already used as life-saving drugs. Until recently, however, the difficulty of working with these microbes has discouraged efforts to develop extremophilic microbes as potential drug reservoirs of the future. Recent technological advances have opened the door to exploring these organisms anew as sources of products that might prove useful in clinical and environmental biotechnology and drug development. Extremophiles features outstanding articles by expert scientists who shed light on broad-ranging areas of progress in the development of smart therapeutics for multiple disease types and products for industrial use. It bridges technological gaps, focusing on critical aspects of extremolytes and the mechanisms regulating their biosynthesis that are relevant to human health and bioenergy, including value-added products of commercial significance as well as other potentially viable products. This groundbreaking guide: Introduces the variety of extremophiles and their extremolytes including extremozymes Provides an overview of the methodologies used to acquire extremophiles Reviews the literature on the diversity of extremophiles Offers tools and criteria for data interpretation of various extremolytes/extremozymes Discusses experimental design problems associated with extremophiles and their therapeutic implications Explores the challenges and possibilities of developing extremolytes for commercial purposes Explains the FDA's regulations on certain microbial bio-products that will be of interest to potential industrialists Extremophiles is an immensely useful resource for graduate students and researchers in biotechnology, clinical biotechnology, microbiology, and applied microbiology.

Mineral trioxide aggregate (MTA) was developed more than 20 years ago to seal the pathways of communication of the root canal system. It’s currently the preferred material used by endodontists because of its superior properties such as its seal and biocompatibility that significantly improves outcomes of endodontic treatments. Dr. Torabinejad, who was the principle investigator of the dental applications of MTA, and leading authorities on this subject provide a clinically focused reference detailing the properties and uses of MTA, including vital pulp therapy (pulp capping, pulpotomy), apexification, pulp regeneration, repair of root perforations, root end filling and root canal filling. Line illustrations and clinical photographs show proper technique. An accompanying website features photographs and video presentations for selected procedures using MTA. Mineral Trioxide Aggregate: Properties and Clinical Applications is an ideal book for dental students and endodontic residents learning procedures for the first time as well as practicing dentists and endodontists who would like to improve outcomes of endodontic treatments.

Dementia is a devastating diagnosis for patients Dementia comes in many forms that can be hard to differentiate. Arriving at an accurate diagnosis without subjecting an already wary patient to unnecessary tests requires clinical acumen. Identifying the correct dementia, and determining a probable prognosis, allows agreement on appropriate management and care with patients and their carers. But how much testing is needed? What do the tests tell you? What management options are available? Dementia provides a progressive approach to help you identify and manage the many forms of this complex and devastating disease. Dr Quinn has assembled a team of expert neurologists and gerontologists to provide the foundation knowledge you need to develop the clinical wisdom for effective dementia care. Dementia clearly explains the diagnosis, investigations and management for Normal pressure hydrocephalus Mild cognitive impairment Alzheimer’s disease Vascular dementia Dementia with Lewy bodies Fronto-temporal dementia Clinical in approach, practical in execution, Dementia helps you diagnose and treat your patients more effectively.

Fibroids are benign growths of the uterus. They are the most common tumours found in women (20-30% of women), usually in later reproductive years. This book covers evidence-based indications for treatment of uterine fibroids in gynecology, the management of fibroids in pregnancy, surgical treatments and outcomes, rare fibroid syndromes, and more.

The rapid developments in magnetic resonance imaging (MRI) over the past 20 years have affirmed its supremacy over most other means of non-invasive exploration of the human body. This progress has had other consequences for imaging physicists: having knowledge about only one of the sides of MRI is nowadays no longer enough to develop new sequences or even to learn more about those that already exist. It is necessary to have a clear and precise view of all the fields explored today by this imaging technique, such as rapid imaging, flows, diffusion, perfusion or even functional MRI. This book aims to allow readers with the basics of physics and mathematics within the field MRI to easily immerse themselves in techniques that are not familiar to them. Pragmatic in approach, moving between the physics underlying the techniques being studied and the clinical examination of images, it will also be of interest to radiologists looking to define protocols or make better use of the images obtained. Contents 1. Flow. 2. Diffusion. 3. Perfusion. 4. Functional MRI. About the Authors Vincent Perrin is a specialist teacher in the fields of physics and chemistry.

From genetics to functional anatomy, cell biology to the equine digestive system, Equine Science, Third Edition covers all the essential scientific knowledge you need for your equine programme. Thoroughly updated, this new edition features a clear, systematic presentation, stunning full-colour photographs and illustrations, chapter summary points and self-assessment questions throughout. Describes the structure and function of the various body systems of the horse Explains the scientific rationale behind modern equine training practices Features new chapters on exercise physiology and the evolution of the horse Reflects the latest scientific advances and changes in the student curriculum Includes new information on circadian rhythms and sleep patterns, the immune system, and hindgut microbiology. A powerful teaching and learning aid, Equine Science, Third Edition is an essential text for students on higher education equine studies and equine science programmes, as well as those studying for BHS qualifications up to BHSII Stage 4 Horse Knowledge and Care.

Essential Microbiology 2nd Edition is a fully revised comprehensive introductory text aimed at students taking a first course in the subject. It provides an ideal entry into the world of microorganisms, considering all aspects of their biology (structure, metabolism, genetics), and illustrates the remarkable diversity of microbial life by devoting a chapter to each of the main taxonomic groupings. The second part of the book introduces the reader to aspects of applied microbiology, exploring the involvement of microorganisms in areas as diverse as food and drink production, genetic engineering, global recycling systems and infectious disease. Essential Microbiology explains the key points of each topic but avoids overburdening the student with unnecessary detail. Now in full colour it makes extensive use of clear line diagrams to clarify sometimes difficult concepts or mechanisms. A companion web site includes further material including MCQs, enabling the student to assess their understanding of the main concepts that have been covered. This edition has been fully revised and updated to reflect the developments that have occurred in recent years and includes a completely new section devoted to medical microbiology. Students of any life science degree course will find this a concise and valuable introduction to microbiology.

Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.

Now available in a fully updated third edition, Equine Ophthalmology is the most comprehensive and current clinical resource for the diagnosis and treatment of ophthalmic disease in horses. Provides complete, authoritative information on the diagnosis and treatment of ophthalmic disease in horses Fully updated with improved figures, the latest research, and new chapters on advanced diagnostics, foal ophthalmology, neuro-ophthalmology, national and international regulations, and an expanded chapter on inherited ocular disease Features contributions from an international group of equine experts, under the editorship of a leading equine veterinary specialist Offers comprehensive coverage of clinical and reference information ideal for specialists, general equine practitioners, and veterinary students alike Includes access to a companion website with expanded content and figures

Endodontic Microbiology, Second Edition presents a comprehensive reference to the microbiology, pathogenesis, management, and healing of endodontic pathosis, emphasizing the importance of biological sciences in understanding and managing endodontic disease and its interaction with systemic health. Provides a major revision to the first book to focus on the problems related to microbes in the root canal and periapical tissues Updates current knowledge in endodontic pathosis, especially regarding next generation sequencing and microbial virulence Presents useful diagrams, images, radiographs, and annotated histological images to illustrate the concepts Emphasizes the importance of biological science in understanding and managing endodontic disease Includes contributions from the leading researchers and educators in the field

Bovine Reproduction is a comprehensive, current reference providing information on all aspects of reproduction in the bull and cow. Offering fundamental knowledge on evaluating and restoring fertility in the bovine patient, the book also places information in the context of herd health where appropriate for a truly global view of bovine theriogenology. Printed in full color throughout, the book includes 83 chapters and more than 550 images, making it the most exhaustive reference available on this topic. Each section covers anatomy and physiology, breeding management, and reproductive surgery, as well as obstetrics and pregnancy wastage in the cow. Bovine Reproduction is a welcome resource for bovine practitioners, theriogenologists, and animal scientists, as well as veterinary students and residents with an interest in the cow.

Recurrent Pregnancy Loss Edited by Ole B Christiansen, MD, D.M.Sc., Rigshospitalet, Copenhagen and AalborgUniversityHospital, Aalborg, Denmark Recurrent Pregnancy Loss is a silent problem for many women The spontaneous loss of a pregnancy in the first 22 weeks is often not recorded as the mother needed no medical or surgical treatment. Women who repeatedly suffer this tragedy can go unheard as a result. Gynecologists can feel unable to help. But they can help. Research is showing how to identify women who suffer recurrent pregnancy loss and which treatments might prevent a further recurrence. Gynecologists are learning how to monitor subsequent pregnancies for the early signals of problems. Recurrent Pregnancy Loss provides a practical approach to this hidden clinical challenge. The highly experienced, international author team explores: How to obtain a relevant history Which investigations to order The physiological reasons behind recurrent pregnancy loss The best approach to treatment How to monitor patients in subsequent pregnancies Clinical in approach, practical in execution, with the patient at the centre, Recurrent Pregnancy Loss guides you as you support your patients.