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This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition

Recent years have seen extensive research in the molecular underpinnings of symbiotic plant-fungal interactions. Molecular Mycorrhizal Symbiosis is a timely collection of work that will bridge the gap between molecular biology, fungal genomics, and ecology. A more profound understanding of mycorrhizal symbiosis will have broad-ranging impacts on the fields of plant biology, mycology, crop science, and ecology. Molecular Mycorrhizal Symbiosis will open with introductory chapters on the biology, structure and phylogeny of the major types of mycorrhizal symbioses. Chapters then review different molecular mechanisms driving the development and functioning of mycorrhizal systems and molecular analysis of mycorrhizal populations and communities. The book closes with chapters that provide an overall synthesis of field and provide perspectives for future research. Authoritative and timely, Molecular Mycorrhizal Symbiosis, will be an essential reference from those working in plant and fungal biology.

Clinical Paediatric Dietetics is a comprehensive guide to the nutritional management of a wide range of paediatric disorders. It provides key information on how conditions may benefit from nutritional support or be ameliorated or resolved by dietary intervention. Covering assessment, requirements and normal healthy eating as well as the dietetic management and nutrition support of inherited metabolic disorders and diseases of all major organ systems, it is an indispensable guide for all those involved in the nutritional treatment of children. Fully revised and updated for its fourth edition, this practical manual now includes links to useful online content and incorporates a range of case studies to place material in clinical context. Written by dietitians for dietitians and officially supported by the British Dietetic Association, Clinical Paediatric Dietetics is an indispensable resource for all healthcare practitioners caring for children.

Small Animal Anesthesia Techniques provides a quick reference to protocols for anesthetizing canine, feline, and exotic animal patients in veterinary practice. This portable companion provides complete information on anesthetic procedures, from the basics of pharmacology, physiology, and equipment to handling challenging procedures and the compromised patient. A companion website features videos, images, and worksheets for calculations. The book offers an overview of the anesthetic process, with tips on how to anticipate and avoid complications, with example protocols for specific patients. Veterinarians and veterinary technicians will find this how-to guide to providing anesthesia to be an ideal resource for fast access to drug dosages, anesthesia protocols, and special considerations for specific procedures.

Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases – for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Nursing Law and Ethics explores a variety of key legal and ethical issues in nursing practice using a thought-provoking and holistic approach. It addresses both what the law requires and what is right, and explores whether these two are always the same. The book provides an overview of the legal, ethical and professional dimensions of nursing, followed by exploration of key issues in greater depth. This edition features updated legislation and new material on patient safety. Key topics are accompanied by both a legal and an ethical perspective, covering both law and ethics Case examples throughout place concepts in a real-life context Written by experts in the field and includes contributions from leading nurses, lawyers and ethicists Accessible, relevant, and comprehensive, this title is ideal for pre- and post-registration nurses.

Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

Metabolism at a Glance presents a concise, illustrated summary of metabolism in health and disease. This essential text is progressively appropriate for introductory through to advanced medical and biochemistry courses. It also provides a succinct review of inborn errors of metabolism, and reference for postgraduate medical practitioners and biomedical scientists who need a resource to quickly refresh their knowledge. Fully updated and extensively illustrated, this new edition of Metabolism at a Glance is now in full colour throughout, and includes new coverage of sports biochemistry; the metabolism of lipids, carbohydrates and cholesterol; glyceroneogenesis, α-oxidation and ω-oxidation of fatty acids. It also features the overlooked “Krebs Uric Acid Cycle”. Metabolism at a Glance offers an accessible introduction to metabolism, and is ideal as a revision aid for students preparing for undergraduate and USMLE Step 1 exams.

'Christopher Johns is an internationally recognised pioneer of reflective practice in nursing and health care.’ – Nursing Standard Becoming a Reflective Practitioner provides a unique insight into reflective practice, exploring the value of using models of reflection, with particular reference to Christopher Johns' own model for structured reflection. Now in its fifth edition, this book has been completely revised and updated to include up-to-date literature and reflective extracts. Contemporary in approach, this definitive text contains a variety of rich and insightful reflective extracts that support the main issues being raised in each chapter, and challenges practitioners and students to question their own practice. Now with further scenarios and case studies included throughout, these extracts provide the reader with access to the experience of reflective representation helping to explicate the way in which reflective practice can inform the wider notion of professional practice. With an increase in professional registration requiring reflective evidence, this new edition of Becoming a Reflective Practitioner is an essential guide to all those using reflection in everyday clinical practice.

Diseases of the Goat, 4th Edition, is a revised and updated edition of the popular tool for veterinarians featuring of all aspects of goat medicine—from initial assessment and examination to diagnosis, treatment, and control of conditions. This highly practical, concise handbook is designed for frequent reference, and is suitable for all those treating and keeping goats. Provides information on to predators, euthanasia, post-mortem technique, and fracture repair Includes expanded coverage of a number of topics to appeal to a wider and more international audience especially in relation to poisonous plants Incorporates the impact of new developments in goat diseases, such as the geographical spread of exotic diseases into new regions

Nursing and Healthcare Research at a Glance is perfect for nursing and healthcare students, as well as newly qualified practitioners and anyone looking for a refresher or introduction to research. Covering a broad range of topics gathered under key sections, this essential book combines informative diagrams and images to provide memorable information for students on one page, and accessible, clearly written text on the facing page. It includes information on a range of quantitative and qualitative research methods, the process of gaining ethical permission, conducting research with special groups including children, and successfully conducting reviews of the literature. Key features include: Clear and informative full colour illustrations throughout An emphasis on need-to-know research information for busy students and healthcare staff A wide range of research methods, currently used in modern healthcare research An impressive line-up of specialist and well-known experts in the field of health and nursing research This book provides quick access to the principles and reality of research and its implementation within the education and practice environment. It is essential reading for anyone in health service education and service settings with limited time who need to draw on research evidence.

Surviving the journey through the Royal Australasian College of Physicians (RACP) examinations requires grit, courage and hard work. The second edition of How To Pass the RACP Written and Clinical Exams is fully updated to help candidates – and those who teach them – dig deep to maximise their chances of success. This insider’s guide takes the candidate through the whole process, from preparing for the Written Exam, through to presenting short and long cases in the Clinical Exam. The authors’ experiences are combined with tips from recent candidates, wisdom from RACP examiners and advice from specialist contributors. Additional chapters for post-exam registrars and supervisors include career planning, providing feedback, preparing for interviews, and organising the Clinical Exam. As well as comprehensive guidance for adult medicine candidates, this new edition includes ‘Paeds Points’ for paediatrics trainees. Containing a wealth of information, pearls of wisdom, real-life examples and practical advice, this light-hearted insider’s guide makes the path through the grueling RACP exams far easier.