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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

With new medications, medical therapies, and increasing numbers of older and medically complex patients seeking dental care, all dentists, hygienists, and students must understand the intersection of common diseases, medical management, and dental management to coordinate and deliver safe care. This new second edition updates all of the protocols and guidelines for treatment and medications and adds more information to aid with patient medical assessments, and clearly organizes individual conditions under three headings: background, medical management, and dental management. Written by more than 25 expert academics and clinicians, this evidence-based guide takes a patient-focused approach to help you deliver safe, coordinated oral health care for patients with medical conditions. Other sections contain disease descriptions, pathogenesis, coordination of care between the dentist and physician, and key questions to ask the patient and physician.

The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potential associated artifacts and pitfalls; the second part addresses clinical applications and novel applications of each method. With a strong focus on the clinical application of each modality or technique in CNS radiology, this book provides in-depth chapter coverage of: • Ultrasound Vascular Imaging (UVI) • Computed Tomography Angiography (CTA) • Magnetic Resonance Vascular imaging (MRV) • Digital subtraction angiography (DSA) • Brain perfusion techniques: CT and MRI • Plaque imaging • Intravascular imaging • Pediatric vascular imaging Along with numerous illustrations and case studies, Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications, and Emerging Techniques is an important book for those faced with choosing from the wide range of choices available for clinical practice.

Prehospital Emergency Medicine (PHEM) is a new and evolving field within Prehospital Care and involves the delivery of safe prehospital critical care to seriously ill or injured patients, and safe transfer to or between hospitals. It covers a broad range of medical and traumatic conditions, interventions, clinical providers and physical environments. ABC of Prehospital Emergency Medicine is the first text to provide a comprehensive overview of this field and with an international team of expert authors is essential reading to anyone involved in the delivery of Prehospital Emergency Medicine and Prehospital Care. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

Manual of Clinical Procedures in the Horse is a detailed step-by-step guide to clinical skills in equine practice. With information on techniques ranging from physical examination and blood sampling to lameness and neurologic exams and other specialized procedures, the book is an aid to confidently and effectively performing procedures used in daily equine practice. Well illustrated with clinical photographs throughout, the book’s focus is on providing thorough, easy-to-understand descriptions of 80 techniques necessary for examining and treating horses. Each topic includes a summary of the purpose, potential complications, equipment and proper restraint for each procedure, with a detailed description of each action for the technique and the rationale behind it. More than 1,100 full-colour clinical photographs demonstrate the techniques. Manual of Clinical Procedures in the Horse is an essential purchase for any veterinary practice seeing equine patients. Key features Details each step for 80 common procedures for veterinary care of the horse Supports veterinarians and technicians in performing techniques in daily equine practice Presents more than 1,100 images depicting the steps described in the text Covers the purpose, potential complications, equipment, restraint, actions and rationale for each procedure Offers a practical patient-side reference to essential techniques in clinical practice, ranging from basic assessment to specialized procedures

A must-have guide for any equine veterinarian, this is a practical and concise handbook on the control of equine parasites. It enables you to advise your clients effectively on evidence-based parasite control programs. The first section of the book reviews the basic biology of internal parasites and the factors influencing their transmission. The second section discusses the general principles of parasite control. The third section provides diagnostic and assessment tools for interpreting clinical, historical and laboratory information. Finally the fourth section contains 20 case studies reflecting the full range of parasites and providing detailed answers and discussions, providing you with the opportunity to practice the application of knowledge and illustrating the concepts of modern parasite control. Handbook of Equine Parasite Control is an invaluable companion for equine veterinary practitioners, veterinary students, equine veterinary technicians and nurses, researchers in equine parasitology, horse owners, and farm and stable managers.

General Practice Cases at a Glance is a workbook of clinical scenarios, ideal for those working in general practice, on their GP rotations, or looking to improve their history-taking, diagnostic and management planning skills. Written by practising teaching GPs, it provides an accessible overview of the richness and complexity of general practice. With 50 engaging consultations, covering all age ranges and a broad spread of clinical areas, each symptom-based chapter begins with the clinical presentation of a patient, before going on to uncover the full history and examination. As you work through each true-to-life case, there are red flag symptoms, useful charts and tables, and further resources to deepen your knowledge. General Practice Cases at a Glance: Is suitable for clinical students, Foundation doctors, and those preparing for the MRCGP's CSA Includes 50 case scenarios from across the medical spectrum, from mental health and paediatrics to musculoskeletal and ENT medicine Is comprehensively illustrated Features current clinical guidelines, and charts and tables to accompany each case Is the companion volume to General Practice at a Glance, ISBN 978-0-470-65551-1, (Awarded First Prize in the Primary health care category at the 2013 BMA Medical Book Awards) but is also a stand-alone resource

Atlas for the Diagnosis of Tumors in the Dog and Cat is a diagnostic tool for determining if samples are abnormal and defining the cause of the abnormality, with 386 clinical images depicting normal and abnormal results. Offers a brief overview of the methods used to produce a diagnosis and prognosis from a biopsy tissue sample Pairs photographs of biopsy samples with photomicrographs of cells obtained via fine needle aspirate Includes a useful chapter covering sample handling, staining, and shipping

The field's bestselling reference, updated with the latest tools, data, and techniques Cost-Effectiveness Analysis in Health is a practical introduction to the tools, methods, and procedures used worldwide to perform cost-effective research. Covering every aspect of a complete cost-effectiveness analysis, this book shows you how to find which data you need, where to find it, how to analyze it, and how to prepare a high-quality report for publication. Designed for the classroom or the individual learner, the material is presented in simple and accessible language for those who lack a biostatistics or epidemiology background, and each chapter includes real-world examples and «tips and tricks» that highlight key information. Exercises throughout allow you to test your understanding with practical application, and the companion website features downloadable data sets for students, as well as lecture slides and a test bank for instructors. This new third edition contains new discussion on meta-analysis and advanced modeling techniques, a long worked example using visual modeling software TreeAge Pro, and updated recommendations from the U.S. Public Health Service's Panel on Cost-Effectiveness in Health and Medicine. Cost-effectiveness analysis is used to evaluate medical interventions worldwide, in both developed and developing countries. This book provides process-specific instruction in a concise, structured format to give you a robust working knowledge of common methods and techniques. Develop a thoroughly fleshed-out research project Work accurately with costs, probabilities, and models Calculate life expectancy and quality-adjusted life years Prepare your study and your data for publication Comprehensive analysis skills are essential for students seeking careers in public health, medicine, biomedical research, health economics, health policy, and more. Cost-Effectiveness Analysis in Health walks you through the process from a real-world perspective to help you build a skillset that's immediately applicable in the field.

Using a practical approach, the Manual of Veterinary Transfusion Medicine and Blood Banking provides veterinary practitioners with evidence-based guidelines to refer to at the clinical practice level. Provides evidence-based information on transfusion medicine and blood banking practices Presents sections on recipient screening, donor selection, blood collection and storage, and how to meet blood product demands Includes useful protocols for transfusions and blood banking relevant to clinical practice Incorporates the balanced perspectives of veterinarians and veterinary technicians Contains information pertaining to large, small, and exotic animals

A practical guide to laboratory diagnosis and treatment of hemostatic disorders. This concise book distils the most clinically up-to-date information on thrombotic and bleeding disorders, including the latest treatment strategies, for key conditions and diseases. Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders. Faced with a bleeding patient, it may be difficult to determine whether blood loss is due to a local factor, or an underlying hemostatic defect. There are a range of laboratory tests which can be performed to identify the cause of bleeding in a patient. This book highlights the tests that can be used in the laboratory to aid diagnosis. Essential Guide to Blood Coagulation has been updated to include the new anticoagulants and now has a dedicated chapter on antiplatelet drugs. This invaluable guide will help all those treating patients to expand their knowledge of hemostatic disorders. TITLES OF RELATED INTEREST Hemophilia and Hemostasis: A Case-Based Approach to Management Second Edition Alice Ma, Harold Roberts, Miguel Escobar ISBN: 978-0-470-65976-2 Quality in Laboratory Hemostasis and Thrombosis Second Edition Steve Kitchen, John Olson, Eric Preston (due May 2013) ISBN: 978-0-470-67119-1

The perfect companion for student midwives in clinical settings, packed full of useful and practical information to help guide and enable you to get the best out of your midwifery placements. This compact, portable text includes what to expect on each type of placement – whether it be working in a low or high risk environment – from how to prepare for practice, what you can anticipate whilst you’re there, the key essential skills to acquire, what pitfalls and problems to be aware of, and how to deal with them if they do arise. Each chapter contains ‘Top Tips’ from current or recently qualified midwifery students, as well as real life student experiences and suggestions for further readings.